eCite Digital Repository

Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol


Bezabhe, WM and Peterson, GM and Bereznicki, L and Chalmers, L and Gee, P, Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol, BMJ Open, 3, (10) Article e003559. ISSN 2044-6055 (2013) [Contribution to Refereed Journal]


Copyright Statement

Copyright 2013 BMJ Licenced under Creative Commons Attribution-Non Commercial 3.0 Unported (CC BY-NC 3.0)

DOI: doi:10.1136/bmjopen-2013-003559


Introduction: Achievement of optimal medication adherence and management of antiretroviral toxicity pose great challenges among Ethiopian patients with HIV/AIDS. There is currently a lack of long-term followup studies that identify the barriers to, and facilitators of, adherence to antiretroviral therapy (ART) in the Ethiopian setting. Therefore, we aim to investigate the level of adherence to ART and a wide range of potential influencing factors, including adverse drug reactions occurring with ART.

Methods and analysis: We are conducting a 1-year prospective cohort study involving adult patients with HIV/AIDS starting on ART between December 2012 and March 2013. Data are being collected on patientsí appointment dates in the ART clinics. Adherence to ART is being measured using pill count, medication possession ratio and patientís self-report. The primary outcome of the study will be the proportion of patients who are adherent to their ART regimen at 3, 6 and 12 months using pill count. Taking 95% or more of the dispensed ART regimen using pill count at given points of time will be considered the optimal level of adherence in this study. Data will be analysed using descriptive and inferential statistical procedures.

Ethics and dissemination: Ethics approval was obtained from the Tasmania Health and Medical Human Research Ethics Committee and Bahir-Dar Universityís Ethics Committee. The results of the study will be reported in peer-reviewed scientific journals, conferences and seminar presentations.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:HIV, AIDS
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Bezabhe, WM (Dr Woldesellassie Bezabhe)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Bereznicki, L (Professor Luke Bereznicki)
UTAS Author:Chalmers, L (Dr Leanne Chalmers)
UTAS Author:Gee, P (Mr Peter Gee)
ID Code:86947
Year Published:2013
Web of Science® Times Cited:8
Deposited By:Pharmacy
Deposited On:2013-11-04
Last Modified:2016-09-28
Downloads:367 View Download Statistics

Repository Staff Only: item control page