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Intestinal epithelium and autophagy: partners in gut homeostasis

Citation

Randall-Demllo, S and Chieppa, M and Eri, RD, Intestinal epithelium and autophagy: partners in gut homeostasis, Frontiers in Immunology, 4 pp. 1-14. ISSN 1664-3224 (2013) [Substantial Review]


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DOI: doi:10.3389/fimmu.2013.00301

Abstract

One of the most significant challenges of cell biology is to understand how each type of cell copes with its specific workload without suffering damage. Among the most intriguing questions concerns intestinal epithelial cells in mammals; these cells act as a barrier between the internally protected region and the external environment that is exposed constantly to food and microbes. A major process involved in the processing of microbes is autophagy. In the intestine, through multiple, complex signaling pathways, autophagy including macroautophagy and xenophagy is pivotal in mounting appropriate intestinal immune responses and anti-microbial protection. Dysfunctional autophagy mechanism leads to chronic intestinal inflammation, such as inflammatory bowel disease (IBD). Studies involving a number of in vitro and in vivo mouse models in addition to human clinical studies have revealed a detailed role for autophagy in the generation of chronic intestinal inflammation. A number of genome-wide association studies identified roles for numerous autophagy genes in IBD, especially in Crohn’s disease. In this review, we will explore in detail the latest research linking autophagy to intestinal homeostasis and how alterations in autophagy pathways lead to intestinal inflammation.

Item Details

Item Type:Substantial Review
Keywords:IBD, autophagy, intestinal epithelium, ATG16L1, IRGM
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Randall-Demllo, S (Mr Sarron Randall-Demllo)
Author:Eri, RD (Associate Professor Raj Eri)
ID Code:86756
Year Published:2013
Web of Science® Times Cited:34
Deposited By:Health Sciences A
Deposited On:2013-10-18
Last Modified:2014-02-07
Downloads:0

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