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Vanilloid Like Agents: Potential Therapeutic Targeting of Platelets?

Citation

Adams, MJ and Almaghrabi, S and Ahuja, KDK and Geraghty, DP, Vanilloid Like Agents: Potential Therapeutic Targeting of Platelets?, Drug Development Research, 74 pp. 450-459. ISSN 1098-2299 (2013) [Substantial Review]


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DOI: doi:10.1002/ddr.21102

Abstract

Capsaicinoids are the ‘hot’ compounds in placental tissues of Capsicum fruits that are responsible for capsicum’s pungency. Capsaicinoids belong to the broader class of vanilloids that activate the non-selective cation channel, transient receptor potential vanilloid-1 (TRPV1). Endogenous vanilloids include arachidonic acid derivatives that have different affinities for TRPV1 and are increasingly recognized as an important group of signaling molecules affecting tissue injury, pain and inflammation. Furthermore, some endogenous vanilloids have high affinity for cannabinoid receptors (CB1 and CB2), which are present in platelets. The most well-known and widely studied plant-derived vanilloid, capsaicin, is reported to have anti-platelet properties but the mechanism of action is uncertain. This article will briefly review the mechanisms involved in platelet activation and aggregation, discuss the properties of vanilloids and their receptor, TRPV1, and discuss whether the effects of vanilloids, and particularly capsaicinoids, on platelets may be exploited for therapeutic benefit.

Item Details

Item Type:Substantial Review
Keywords:Platelets, vanilloids, capsaicinoids, transient receptor potential vanilloid-, cardiovascular disease
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Adams, MJ (Dr Murray Adams)
Author:Almaghrabi, S (Ms Safa Almaghrabi)
Author:Ahuja, KDK (Dr Kiran Ahuja)
Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:86588
Year Published:2013
Deposited By:Health Sciences A
Deposited On:2013-09-29
Last Modified:2014-06-05
Downloads:0

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