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Association between hip and knee cartilage measured using radiographs and magnetic resonance imaging: the Tasmanian Older Adult Cohort Study

Citation

Khan, HI and Aitken, D and Zhai, G and Ding, C and Pelletier, J-P and Pelletier, JM and Cicuttini, F and Blizzard, L and Jones, G, Association between hip and knee cartilage measured using radiographs and magnetic resonance imaging: the Tasmanian Older Adult Cohort Study, Rheumatology, 52, (11) pp. 2009-2015. ISSN 0080-2727 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Oxford University Press

DOI: doi:10.1093/rheumatology/ket243

Abstract

Objective: Cartilage loss is a key pathological feature of OA and can be assessed indirectly using radiography or directly through MRI. A number of cross-sectional studies have suggested that primary generalized osteoarthritis (PGOA) may be a distinct disease, but despite the high frequency of involvement of the hip and the knee joints in OA, very few studies have looked at the radiographic association between these two joints, and none has done so using MRI. The aim of this study was to examine the association of hip and knee cartilage measured by both radiography and MRI.

Methods: We studied 151 participants from the Tasmanian Older Adult Cohort (TASOAC) study, who were selected randomly from the southern Tasmanian electoral rolls. MRI was used to assess hip and knee cartilage volume and radiography was used to assess joint space narrowing (JSN). Correlation analyses were used to compare cartilage volume measurements and JSN.

Results: In adjusted analysis, there was a consistent, positive association between knee and hip cartilage volume that was best for total knee cartilage volume (r = 0.16-0.40, all P < 0.05). In contrast, there was at best a weak correlation, depending on the site, between hip and knee JSN (r = -0.01 to 0.21).

Conclusion: Hip and knee cartilage volume are more strongly associated than hip and knee JSN, suggesting a commonality of cartilage volume at different anatomic sites. The weaker radiographic association may reflect less measurement error with MRI or the contribution of multiple structures to joint space in the knee.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, knee, hip, cartilage volume, MRI, X-ray
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Khan, HI (Dr Hussain Khan)
Author:Aitken, D (Dr Dawn Aitken)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Jones, G (Professor Graeme Jones)
ID Code:86230
Year Published:2013
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-08-29
Last Modified:2017-11-02
Downloads:0

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