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Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis


Disanto, G and Hall, C and Lucas, R and Ponsonby, A-L and Berlanga-Taylor, AJ and Giovannoni, G and Ramagopalan, SV and Chapman, C and Coulthard, A and Dear, K and Dwyer, T and Kilpatrick, T and McMichael, T and Pender, MP and Taylor, B and Valery, P and van der Mei, I and Williams, D, Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis, Multiple Sclerosis, 19, (10) pp. 1355-1358. ISSN 1352-4585 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Sage publications

DOI: doi:10.1177/1352458513477231


Gene-environment interactions may shed light on the mechanisms underlying multiple sclerosis (MS). We pooled data from two case-control studies on incident demyelination and used different methods to assess interaction between HLA-DRB1*15 (DRB1-15) and history of infectious mononucleosis (IM). Individuals exposed to both factors were at substantially increased risk of disease (OR=7.32, 95% CI=4.92-10.90). In logistic regression models, DRB1-15 and IM status were independent predictors of disease while their interaction term was not (DRB1-15*IM: OR=1.35, 95% CI=0.79-2.23). However, interaction on an additive scale was evident (Synergy index=2.09, 95% CI=1.59-2.59; excess risk due to interaction=3.30, 95%CI=0.47-6.12; attributable proportion due to interaction=45%, 95% CI=22-68%). This suggests, if the additive model is appropriate, the DRB1-15 and IM may be involved in the same causal process leading to MS and highlights the benefit of reporting gene-environment interactions on both a multiplicative and additive scale.

Item Details

Item Type:Refereed Article
Keywords:HLA-DRBI*15, infectious mononucleosis, interaction, multiple sclerosis
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Taylor, B (Professor Bruce Taylor)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:86213
Year Published:2013
Funding Support:National Health and Medical Research Council (490020)
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-08-29
Last Modified:2017-11-07

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