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When to prevent cardiovascular disease? As early as possible: lessons from prospective cohorts beginning in childhood


Magnussen, CG and Smith, KJ and Juonala, M, When to prevent cardiovascular disease? As early as possible: lessons from prospective cohorts beginning in childhood, Current Opinion in Cardiology, 28, (5) pp. 561-568. ISSN 0268-4705 (2013) [Substantial Review]

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DOI: doi:10.1097/HCO.0b013e32836428f4


PURPOSE OF REVIEW: To detail recent developments linking modifiable youth risk factors with preclinical markers of cardiovascular disease such as carotid artery intima-media thickness, pulse-wave velocity (PVW) and large artery stiffness, brachial artery flow-mediated dilatation, left ventricular geometry, and coronary artery calcification in adulthood. RECENT FINDINGS: Population-based data from prospective cohort studies beginning in youth with follow-up into adulthood have shown that the modifiable youth risk factors of elevated blood lipids, blood pressure, and adiposity, smoking (active and passive), metabolic disorders, physical inactivity, low cardiorespiratory fitness, and diet associate with preclinical markers of cardiovascular disease in adulthood. The data suggest that, in some instances, those who amend their trajectory by not maintaining these risk factors into adulthood experience reductions in preclinical markers to levels associated with never having had the risk factor. SUMMARY: Though avoidance of risk factors in youth is ideal, there is still a window for intervention where long-lasting cardiovascular effects might be avoided. Health-enhancing changes in the rates of active and passive smoking, adiposity, increased physical activity, accentuated fitness, modified diet, and socioeconomic position in the transition from youth to adulthood might be important in modifying an individual's trajectory from high risk in youth to low risk in adulthood.

Item Details

Item Type:Substantial Review
Keywords:cardiovascular disease, carotid intima-media thickness, modifiable risk factors, pediatric, review
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:Smith, KJ (Dr Kylie Smith)
ID Code:85918
Year Published:2013
Funding Support:National Health and Medical Research Council (1037559)
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-08-14
Last Modified:2013-12-05
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