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Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1
Citation
Grimmond, S and Weber, G and Larsson, C and Walters, M and Teh, BT and Shepherd, JJ and Nordenskjold, M and Hayward, N, Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1, Human Genetics, 95, (4) pp. 455-458. ISSN 0340-6717 (1995) [Refereed Article]
Abstract
The MEN1 gene is considered to be a tumour suppressor gene and has been localised to a 1-Mb region of 11q13.1. In this study, we report the physical localisation of the 13-kDa FK506 and rapamycin binding protein gene (FKBP2) to the cosmid marker D11S750, which is located inside the MEN1 region of non-recombination. The product of this gene is involved in signal transduction and is thus a candidate cell growth regulator or tumour suppressor gene. Northern studies have revealed that FKBP2 is expressed in those tissues predisposed to hyperplasia in MEN1; however, single-strand conformation polymorphism analysis and direct sequencing of DNAs from affected members of MEN1 kindreds and sporadic tumour DNAs have been performed and no mutations have been found. These studies exclude FKBP2 as a candidate gene for MEN1. © 1995 Springer-Verlag.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biological Sciences |
| Research Group: | Biochemistry and Cell Biology |
| Research Field: | Cell Metabolism |
| Objective Division: | Health |
| Objective Group: | Other Health |
| Objective Field: | Health not elsewhere classified |
| Author: | Shepherd, JJ (Professor Joseph Shepherd) |
| ID Code: | 8560 |
| Year Published: | 1995 |
| Web of Science® Times Cited: | 20 |
| Deposited By: | Surgery |
| Deposited On: | 1996-08-01 |
| Last Modified: | 2011-08-25 |
| Downloads: | 0 |
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