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Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1

Citation

Grimmond, S and Weber, G and Larsson, C and Walters, M and Teh, BT and Shepherd, JJ and Nordenskjold, M and Hayward, N, Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1, Human Genetics, 95, (4) pp. 455-458. ISSN 0340-6717 (1995) [Refereed Article]

DOI: doi:10.1007/BF00208976

Abstract

The MEN1 gene is considered to be a tumour suppressor gene and has been localised to a 1-Mb region of 11q13.1. In this study, we report the physical localisation of the 13-kDa FK506 and rapamycin binding protein gene (FKBP2) to the cosmid marker D11S750, which is located inside the MEN1 region of non-recombination. The product of this gene is involved in signal transduction and is thus a candidate cell growth regulator or tumour suppressor gene. Northern studies have revealed that FKBP2 is expressed in those tissues predisposed to hyperplasia in MEN1; however, single-strand conformation polymorphism analysis and direct sequencing of DNAs from affected members of MEN1 kindreds and sporadic tumour DNAs have been performed and no mutations have been found. These studies exclude FKBP2 as a candidate gene for MEN1. © 1995 Springer-Verlag.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Shepherd, JJ (Professor Joseph Shepherd)
ID Code:8560
Year Published:1995
Web of Science® Times Cited:20
Deposited By:Surgery
Deposited On:1996-08-01
Last Modified:2011-08-25
Downloads:0

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