File(s) not publicly available
Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1
journal contribution
posted on 2023-05-16, 10:18 authored by Grimmond, S, Weber, G, Larsson, C, Walters, M, Teh, BT, Shepherd, JJ, Nordenskjold, M, Hayward, NThe MEN1 gene is considered to be a tumour suppressor gene and has been localised to a 1-Mb region of 11q13.1. In this study, we report the physical localisation of the 13-kDa FK506 and rapamycin binding protein gene (FKBP2) to the cosmid marker D11S750, which is located inside the MEN1 region of non-recombination. The product of this gene is involved in signal transduction and is thus a candidate cell growth regulator or tumour suppressor gene. Northern studies have revealed that FKBP2 is expressed in those tissues predisposed to hyperplasia in MEN1; however, single-strand conformation polymorphism analysis and direct sequencing of DNAs from affected members of MEN1 kindreds and sporadic tumour DNAs have been performed and no mutations have been found. These studies exclude FKBP2 as a candidate gene for MEN1. © 1995 Springer-Verlag.
History
Publication title
Human GeneticsVolume
95Issue
4Pagination
455-458ISSN
0340-6717Department/School
Tasmanian School of MedicinePublisher
Springer-VerlagPlace of publication
175 Fifth Ave, New York, USA, Ny, 10010Repository Status
- Restricted