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Epigenetic regulation of inducible gene expression in the immune system
Citation
Lim, PS and Li, J and Holloway, AF and Rao, S, Epigenetic regulation of inducible gene expression in the immune system, Immunology, 139, (3) pp. 285-293. ISSN 0019-2805 (2013) [Refereed Article]
Copyright Statement
Copyright 2013 John Wiley & Sons.
Abstract
Summary: T cells are exquisitely poised to respond rapidly to pathogens and have proved an instructive model for exploring the regulation of inducible genes. Individual genes respond to antigenic stimulation in different ways, and it has become clear that the interplay between transcription factors and the chromatin platform of individual genes governs these responses. Our understanding of the complexity of the chromatin platform and the epigenetic mechanisms that contribute to transcriptional control has expanded dramatically in recent years. These mechanisms include the presence/absence of histone modification marks, which form an epigenetic signature to mark active or inactive genes. These signatures are dynamically added or removed by epigenetic enzymes, comprising an array of histone-modifying enzymes, including the more recently recognized chromatin-associated signalling kinases. In addition, chromatin-remodelling complexes physically alter the chromatin structure to regulate chromatin accessibility to transcriptional regulatory factors. The advent of genome-wide technologies has enabled characterization of the chromatin landscape of T cells in terms of histone occupancy, histone modification patterns and transcription factor association with specific genomic regulatory regions, generating a picture of the T-cell epigenome. Here, we discuss the multi-layered regulation of inducible gene expression in the immune system, focusing on the interplay between transcription factors, and the T-cell epigenome, including the role played by chromatin remodellers and epigenetic enzymes. We will also use IL2, a key inducible cytokine gene in T cells, as an example of how the different layers of epigenetic mechanisms regulate immune responsive genes during T-cell activation. © 2013 John Wiley & Sons Ltd.
Item Details
Item Type: | Refereed Article |
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Keywords: | genomics; T cells; transcription factors/gene regulation |
Research Division: | Biological Sciences |
Research Group: | Genetics |
Research Field: | Epigenetics (incl. genome methylation and epigenomics) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Holloway, AF (Associate Professor Adele Holloway) |
ID Code: | 85566 |
Year Published: | 2013 |
Web of Science® Times Cited: | 37 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2013-07-18 |
Last Modified: | 2017-11-07 |
Downloads: | 0 |
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