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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Citation

Al Olama, AA and Kote-Jarai, Z and Schumacher, FR and Wiklund, F and Berndt, SI and Benlloch, S and Giles, GG and Severi, G and Neal, DE and Hamdy, FC and Donovan, JL and Hunter, DJ and Henderson, BE and Thun, MJ and Gaziano, M and Giovannucci, EL and Siddiq, A and Travis, RC and Cox, DG and Canzian, F and Riboli, E and Key, TJ and Andriole, G and Albanes, D and Hayes, RB and Schleutker, J and Auvinen, A and Tammela, TLJ and Weischer, M and Stanford, JL and Ostrander, EA and Cybulski, C and Lubinski, J and Thibodeau, SN and Schaid, DJ and Sorensen, KD and Batra, J and Clements, JA and Chambers, S and Aitken, J and Gardiner, RA and Maier, C and Vogel, W and Dork, T and Brenner, H and Habuchi, T and Ingles, S and John, EM and Dickinson, JL and Cannon-Albright, L and Teixeira, MR and Kaneva, R and Zhang, HW and Lu, YJ and Park, JY and Cooney, KA and Muir, KR and Leongamornlert, DA and Saunders, E and Tymrakiewicz, M and Mahmud, N and Guy, M and Govindasami, K and O'Brien, LT and Wilkinson, RA and Hall, AL and Sawyer, EJ and Dadaev, T and Morrison, J and Dearnaley, DP and Horwich, A and Huddart, RA and Khoo, VS and Parker, CC and Van As, N and Woodhouse, CJ and Thompson, A and Dudderidge, T and Ogden, C and Cooper, CS and Lophatonanon, A and Southey, MC and Hopper, JL and English, D and Virtamo, J and Le Marchand, L and Campa, D and Kaaks, R and Lindstrom, S and Diver, WR and Gapstur, S and Yeager, M and Cox, A and Stern, MC and Corral, R and Aly, M and Isaacs, W and Adolfsson, J and Xu, J and Zheng, SL and Wahlfors, T and Taari, K and Kujala, P and Klarskov, P and Nordestgaard, BG and Roder, MA and Frikke-Schmidt, R and Bojesen, SE and Fitzgerald, LM and Kolb, S and Kwon, EM and Karyadi, DM and Orntoft, TF and Borre, M and Rinckleb, A and Luedeke, M and Herkommer, K and Meyer, A and Serth, J and Marthick, JR and Patterson, B and Wokolorczyk, D and Spurdle, A and Lose, F and McDonnell, SK and Joshi, AD and Shahabi, A and Pinto, P and Santos, J and Ray, A and Sellers, TA and Lin, HY and Stephenson, RA and Teerlink, C and Muller, H and Rothenbacher, D and Tsuchiya, N and Narita, S and Cao, GW and Slavov, C and Mitev, V and Chanock, S and Gronberg, H and Haiman, CA and Kraft, P and Easton, DF and Eeles, RA and The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators; The Australian Prostate Cancer Bioresource; The PRACTICAL Consortium, A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease, Human Molecular Genetics, 22, (2) pp. 408-415. ISSN 0964-6906 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 the authors.

DOI: doi:10.1093/hmg/dds425

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Item Details

Item Type:Refereed Article
Keywords:genes, prostate cancer
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
Author:Marthick, JR (Mr James Marthick)
Author:Patterson, B (Dr Briony Patterson)
ID Code:85506
Year Published:2013
Web of Science® Times Cited:64
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-07-11
Last Modified:2015-11-04
Downloads:0

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