Scott, D and Hayes, A and Sanders, KM and Aitken, D and Ebeling, PR and Jones, G, Operational definitions of sarcopenia and their associations with 5-year changes in falls risk in community-dwelling middle-aged and older adults, Osteoporosis International, 25, (1) pp. 187-193. ISSN 1433-2965 (2014) [Refereed Article]
Copyright 2013 International Osteoporosis Foundation and National Osteoporosis Foundation
Summary: Sarcopenia may be diagnosed in the clinic using operational definitions based on low muscle mass or function. This prospective, population-based study revealed that sex-specific associations may exist between operational definitions of sarcopenia and falls in community-dwelling middle-aged and older adults.
Introduction:The objective of this study is to verify associations between sarcopenia and falls risk and to determine changes in sarcopenia prevalence over 5 years in middle-aged and older men and women according to different anthropometric and performance-based operational definitions.
Methods: N = 681 volunteers (48 % female; mean ± SD age 61.4 ± 7.0 years) participated in baseline and follow-up assessments (mean 5.1 ± 0.5 years later). Appendicular lean mass (ALM) was assessed by dual-energy X-ray absorptiometry, hand grip (HGS) and lower-limb (LLS) strength were assessed by dynamometry, and falls risk was determined using the physiological profile assessment. Anthropometric definitions (ALM/height squared [ALM-H], ALM/weight × 100 and a residuals method [ALM-R]) and performance-based definitions (HGS, LLS and upper- and lower-limb muscle quality [LMQ]) of sarcopenia were examined. The lowest 20 % of the sex-specific distribution for each definition at baseline was classified as sarcopenia.
Results: Sarcopenia prevalence increased after 5 years for all operational definitions except ALM-H (men: -4.0 %; women: -5.5 %). Men classified with sarcopenia according to anthropometric definitions, and women classified with sarcopenia according to performance-based definitions, had significant increases in falls risk over 5 years (all P < 0.05) compared to individuals without sarcopenia. Significant sex interactions were observed for ALM-R, LLS and LMQ (all P < 0.05) definitions.
Conclusions:Sarcopenia prevalence generally increases at a higher rate when assessed using performance-based definitions. Sarcopenia is associated with increases in falls risk over 5 years in community-dwelling middle-aged and older adults, but sex-specific differences may exist according to different anthropometric or performance-based definitions.
|Item Type:||Refereed Article|
|Keywords:||sarcopenia, falls risk, falls, muscle mass, muscle strength|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Clinical Sciences not elsewhere classified|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified|
|Author:||Aitken, D (Dr Dawn Aitken)|
|Author:||Jones, G (Professor Graeme Jones)|
|Year Published:||2014 (online first 2013)|
|Web of Science® Times Cited:||41|
|Deposited By:||Menzies Institute for Medical Research|
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