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Role for the Microvasculature in Glucose Uptake in Skeletal Muscle


Premilovac, D and Ng, HLH and Richards, SM and Bradley, EA and Dwyer, RM and Rattigan, S and Keske, MA, Role for the Microvasculature in Glucose Uptake in Skeletal Muscle, Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments), Nova Science Publishers, Johnson CC and Williams DB (ed), New York, pp. 109-139. ISBN 978-1-62618-670-5 (2013) [Research Book Chapter]

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Copyright 2013 Nova Science Publishers Inc

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Skeletal muscle is an important site for insulin action and is responsible for ~80% of insulin-mediated glucose disposal following a meal. Insulin stimulates muscle glucose uptake in two ways: firstly insulin improves the delivery of glucose to muscle cells by increasing blood flow to the microvasculature and transport across the endothelium in contact with the myocyte, and secondly by increasing glucose uptake across the muscle cell membrane via activation of the insulin signalling pathway leading to the recruitment of a specific glucose transporter (GLUT4) to the cell membrane. During insulin resistance and type 2 diabetes, both of these responses to insulin can become impaired. Here we review the considerable body of literature showing that insulin-stimulated microvascular recruitment improves the delivery of insulin and glucose to the myocyte to augment insulinís metabolic action, and that vascular actions of insulin are lost during insulin resistance and type 2 diabetes. Furthermore we discuss more recent evidence to suggest that microvascular insulin responses are lost prior to and independently of the development of myocyte insulin resistance.

Item Details

Item Type:Research Book Chapter
Keywords:microvasculature, insulin action, skeletal muscle
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Premilovac, D (Dr Dino Premilovac)
UTAS Author:Ng, HLH (Miss Huei Ng)
UTAS Author:Richards, SM (Dr Stephen Richards)
UTAS Author:Bradley, EA (Miss Eloise Bradley)
UTAS Author:Dwyer, RM (Dr Renee Ross)
UTAS Author:Rattigan, S (Professor Stephen Rattigan)
UTAS Author:Keske, MA (Dr Michelle Keske)
ID Code:85377
Year Published:2013
Funding Support:National Health and Medical Research Council (490034)
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-07-02
Last Modified:2017-10-16

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