eCite Digital Repository
The Role of Inflammasomes in Intestinal Inflammation
Citation
Ranson, NM and Eri, RD, The Role of Inflammasomes in Intestinal Inflammation, American Journal of Medical and Biological Research, 1, (3) pp. 64-76. ISSN 2328-4080 (2013) [Substantial Review]
![]() | PDF Pending copyright assessment - Request a copy 423Kb |
Abstract
Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis cause severe gastrointestinal dysfunction and reduce the quality of life. Despite intensive research, the exact pathogenesis of IBD remains elusive. Mucosal immune responses are central to intestinal homeostasis. Immune responses in the gut are orchestrated through innate and adaptive immune responses. In this paper, we will focus on innate immune responses mounted through Toll-like receptors (TLR) and NOD-like receptors (NLR). Recently, inflammasome protein complexes working through Iinterleukin-1β and 18 have been shown to play a pivotal role in the maintenance of gut homeostasis. Recent research work indicates NLRs such as NLRP1, 3, 6 and 12 provide functional roles in inflammasome activation in intestinal physiology. This review highlights the role of inflammasomes in intestinal health and dysfunction.
Item Details
Item Type: | Substantial Review |
---|---|
Keywords: | inflammatory bowel disease, colitis, inflammasomes, innate immunity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Immunology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Ranson, NM (Dr Nicole Ranson) |
UTAS Author: | Eri, RD (Associate Professor Raj Eri) |
ID Code: | 85359 |
Year Published: | 2013 |
Deposited By: | Health Sciences A |
Deposited On: | 2013-07-02 |
Last Modified: | 2013-07-02 |
Downloads: | 0 |
Repository Staff Only: item control page