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Functional role of left PMd and left M1 during preparation and execution of left hand movements in older adults

Citation

Fujiyama, H and Hinder, MR and Summers, JJ, Functional role of left PMd and left M1 during preparation and execution of left hand movements in older adults, Journal of Neurophysiology, 110, (5) pp. 1062-1069. ISSN 0022-3077 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 The American Physiological Society

DOI: doi:10.1152/jn.00075.2013

Abstract

A disruptive transcranial magnetic stimulation (TMS) approach was used to determine whether the increased frontal activation and reduced hemispheric laterality brain activation patterns observed in older adults during motor tasks play a functional role. Young and older adults abducted their left index finger as soon as possible following a visual imperative signal presented 500ms after a warning signal. TMS was applied to the dorsal premotor (PMd) or primary motor (M1) cortex in the left or right hemisphere at seven times during response preparation and execution. Both groups exhibited faster reaction times in their left hand following stimulation of the left PMd (i.e., ipsilateral to the responding hand) relative to trials with no TMS, indicating a functional role of the left PMd in the regulation of impulse control. This result also suggests that the function of the left PMd appears to be unaffected by the healthy aging process. Right M1 TMS resulted in a response time delay in both groups. Only for older adults did left M1 stimulation delay responses, suggesting the involvement of ipsilateral motor pathways in the preparation of motor actions in older adults.

Item Details

Item Type:Refereed Article
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Sensory Processes, Perception and Performance
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in Psychology and Cognitive Sciences
Author:Fujiyama, H (Dr Hakuei Fujiyama)
Author:Hinder, MR (Dr Mark Hinder)
Author:Summers, JJ (Professor Jeffery Summers)
ID Code:85175
Year Published:2013
Web of Science® Times Cited:4
Deposited By:Psychology
Deposited On:2013-06-17
Last Modified:2017-11-05
Downloads:0

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