eCite Digital Repository
Different regulatory mechanisms in protozoan parasitic infections
Citation
Kling, JC and Korner, H, Different regulatory mechanisms in protozoan parasitic infections, International Journal for Parasitology, 43, (6) pp. 417-425. ISSN 0020-7519 (2013) [Substantial Review]
DOI: doi:10.1016/j.ijpara.2013.02.001
Abstract
The immune response to the protozoan pathogens, Leishmania spp., Trypanosoma spp. and Plasmodium spp., has been studied extensively with particular focus on regulation of the immune response by immunological mechanisms. More specifically, in diseases caused by parasites, immunosuppression frequently prevents immunopathology that can injure the host. However, this allows a small number of parasites to evade the immune response and remain in the host after a clinical cure. The consequences can be chronic infections, which establish a zoonotic or anthroponotic reservoir. This review will highlight some of the identified regulatory mechanisms of the immune system that govern immune responses to parasitic diseases, in particular leishmaniasis, trypanosomiasis and malaria, and discuss implications for the development of efficient vaccines against these diseases.
Item Details
Item Type: | Substantial Review |
---|---|
Keywords: | Leishmania; Trypanosoma; Plasmodium; Regulatory T cells; Alternatively activated macrophages; iNOS; Arginase 1 |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Immunology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Kling, JC (Miss Jessica Kling) |
UTAS Author: | Korner, H (Professor Heinrich Korner) |
ID Code: | 84950 |
Year Published: | 2013 |
Web of Science® Times Cited: | 9 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2013-06-06 |
Last Modified: | 2013-06-06 |
Downloads: | 0 |
Repository Staff Only: item control page