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Occupational Exposure and Risk of Central Nervous System Demyelination

Citation

Valery, PC and Lucas, RM and Williams, DB and Pender, MP and Chapman, C and Coulthard, A and Dear, K and Dwyer, T and Kilpatrick, TJ and McMichael, AJ and van der Mei, I and Taylor, BV and Ponsonby, A-L, Occupational Exposure and Risk of Central Nervous System Demyelination, American Journal of Epidemiology, 177, (9) pp. 954-961. ISSN 0002-9262 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 The Authors.

DOI: doi:10.1093/aje/kws361

Abstract

Inconsistent evidence exists regarding the association between work-related factors and risk of multiple sclerosis (MS). We examined the association between occupational exposures and risk of a first clinical diagnosis of central nervous system demyelination (FCD), which is strongly associated with progression to MS, in a matched case-control study of 276 FCD cases and 538 controls conducted in Australia (2003-2006). Using a personal residence and work calendar, information on occupational history and exposure to chemicals and animals was collected through face-to-face interviews. Few case-control differences were noted. Fewer cases had worked as professionals (6 years) than controls (adjusted odds ratio (AOR) = 0.60, 95% confidence interval (CI): 0.37, 0.96). After further adjustment for number of children, cases were more likely to have ever been exposed to livestock than controls (AOR = 1.54, 95% CI: 1.03, 2.29). Among women, there was an increase in FCD risk associated with 10 or more years of exposure to livestock (AOR = 2.78, 95% CI: 1.22, 6.33) or 6 or more years of farming (AOR = 2.00, 95% CI: 1.23, 3.25; also adjusted for number of children). Similar findings were not evident among men. Thus, farming and exposure to livestock may be important factors in the development of FCD among women, with this finding further revealed after the confounding effect of parity or number of children is considered.

Item Details

Item Type:Refereed Article
Keywords:confounding, multiple sclerosis, occupational exposure, risk factors
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:84741
Year Published:2013
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-05-29
Last Modified:2017-11-07
Downloads:0

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