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Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy

Citation

Thavendiranathan, P and Grant, AD and Negishi, T and Plana, JC and Popovic, ZB and Marwick, TH, Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy, Journal of the American College of Cardiology, 61, (1) pp. 77-84. ISSN 0735-1097 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 American College of Cardiology Foundation

DOI: doi:10.1016/j.jacc.2012.09.035

Abstract

Objectives: The aim of this study was to identify the best echocardiographic method for sequential quantification of left ventricular (LV) ejection fraction (EF) and volumes in patients undergoing cancer chemotherapy.

Background: Decisions regarding cancer therapy are based on temporal changes of EF. However the method for EF measurement with the lowest temporal variability is unknown.

Methods: We selected patients in whom stable function in the face of chemotherapy for breast cancer was defined by stability of global longitudinal strain (GLS) at up to 5 time points (baseline, 3, 6, 9, and 12 months). In this way, changes in EF were considered to reflect temporal variability of measurements rather than cardiotoxicity. A comprehensive echocardiogram consisting of 2-dimensional (2D) and 3-dimensional (3D) acquisitions with and without contrast administration was performed at each time point. Stable LV function was defined as normal GLS (≤ -16.0%) at each examination. The EF and volumes were measured with 2D-biplane Simpson's method, 2D-triplane, and 3-dimensional echocardiography (3DE) by 2 investigators blinded to any clinical data. Inter-, intra-, and test-retest variability were assessed in a subgroup. Variability was assessed by analysis of variance and compared with Levene's or t test.

Results: Among 56 patients (all female, 54 13 years of age), noncontrast 3D EF, end-diastolic volume, and end-systolic volume had significantly lower temporal variability than all other methods. Contrast only decreased the temporal variability of LV end-diastolic volume measurements by the 2D biplane method. Our data suggest that a temporal variability in EF of 0.06 might occur with noncontrast 3DE due to physiological differences and measurement variability, whereas this might be > 0.10 with 2D methods. Overall, 3DE also had the best intra- and inter-observer as well as test-retest variability.

Conclusions: Noncontrast 3DE was the most reproducible technique for LVEF and LV volume measurements over 1 year of follow-up.

Item Details

Item Type:Refereed Article
Keywords:3D echocardiography, chemotherapy, interobserver test re-test variability, interobserver variability, longitudinal variability
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:84512
Year Published:2013
Web of Science® Times Cited:160
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-05-15
Last Modified:2017-11-03
Downloads:0

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