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Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy
Citation
Thavendiranathan, P and Grant, AD and Negishi, T and Plana, JC and Popovic, ZB and Marwick, TH, Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy, Journal of the American College of Cardiology, 61, (1) pp. 77-84. ISSN 0735-1097 (2013) [Refereed Article]
Copyright Statement
Copyright 2013 American College of Cardiology Foundation
DOI: doi:10.1016/j.jacc.2012.09.035
Abstract
Objectives: The aim of this study was to identify the best echocardiographic method for sequential quantification of left ventricular (LV) ejection fraction (EF) and volumes in patients undergoing cancer chemotherapy.
Background: Decisions regarding cancer therapy are based on temporal changes of EF. However the method for EF measurement with the lowest temporal variability is unknown.
Methods: We selected patients in whom stable function in the face of chemotherapy for breast cancer was defined by stability of global longitudinal strain (GLS) at up to 5 time points (baseline, 3, 6, 9, and 12 months). In this way, changes in EF were considered to reflect temporal variability of measurements rather than cardiotoxicity. A comprehensive echocardiogram consisting of 2-dimensional (2D) and 3-dimensional (3D) acquisitions with and without contrast administration was performed at each time point. Stable LV function was defined as normal GLS (≤ -16.0%) at each examination. The EF and volumes were measured with 2D-biplane Simpson's method, 2D-triplane, and 3-dimensional echocardiography (3DE) by 2 investigators blinded to any clinical data. Inter-, intra-, and test-retest variability were assessed in a subgroup. Variability was assessed by analysis of variance and compared with Levene's or t test.
Results: Among 56 patients (all female, 54 ± 13 years of age), noncontrast 3D EF, end-diastolic volume, and end-systolic volume had significantly lower temporal variability than all other methods. Contrast only decreased the temporal variability of LV end-diastolic volume measurements by the 2D biplane method. Our data suggest that a temporal variability in EF of 0.06 might occur with noncontrast 3DE due to physiological differences and measurement variability, whereas this might be > 0.10 with 2D methods. Overall, 3DE also had the best intra- and inter-observer as well as test-retest variability.
Conclusions: Noncontrast 3DE was the most reproducible technique for LVEF and LV volume measurements over 1 year of follow-up.
Item Details
Item Type: | Refereed Article |
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Keywords: | 3D echocardiography, chemotherapy, interobserver test re-test variability, interobserver variability, longitudinal variability |
Research Division: | Medical and Health Sciences |
Research Group: | Cardiorespiratory Medicine and Haematology |
Research Field: | Cardiology (incl. Cardiovascular Diseases) |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Cardiovascular System and Diseases |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 84512 |
Year Published: | 2013 |
Web of Science® Times Cited: | 258 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2013-05-15 |
Last Modified: | 2017-11-03 |
Downloads: | 0 |
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