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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

journal contribution
posted on 2023-05-17, 17:34 authored by Cui, H, Freeman, C, Glenn JacobsonGlenn Jacobson, David SmallDavid Small
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD.

History

Publication title

IUBMB Life

Volume

65

Pagination

108-120

ISSN

1521-6543

Department/School

Menzies Institute for Medical Research

Publisher

Wiley

Place of publication

325 Chestnut St, Suite 800, Philadelphia, USA, Pa, 19106

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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