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Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

Citation

Cui, H and Freeman, C and Jacobson, GA and Small, DH, Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease, IUBMB Life, 65, (2) pp. 108-120. ISSN 1521-6543 (2013) [Refereed Article]

DOI: doi:10.1002/iub.1118

Abstract

Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD.

Item Details

Item Type:Refereed Article
Keywords:glycosaminoglycans, proteoglycan, brain development, Alzheimer's disease
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Cui, H (Mr Hao Cui)
Author:Jacobson, GA (Dr Glenn Jacobson)
Author:Small, DH (Professor David Small)
ID Code:84497
Year Published:2013
Web of Science® Times Cited:30
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-05-15
Last Modified:2017-11-06
Downloads:0

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