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CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Citation

Wiede, F and Fromm, PD and Comerford, I and Kara, E and Bannan, J and Schuh, W and Ranasinghe, C and Tarlinton, D and Winkler, T and McColl, SR and Korner, H, CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse, Immunology and Cell Biology, 91, (5) pp. 335-339. ISSN 0818-9641 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Australasian Society for Immunology Inc.

DOI: doi:10.1038/icb.2013.14

Abstract

The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on na´ve B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6/ mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6/ B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.

Item Details

Item Type:Refereed Article
Keywords:B cells, germinal centers, chemokine receptor
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Bannan, J (Ms Jennifer Bannan)
Author:Korner, H (Professor Heinrich Korner)
ID Code:84340
Year Published:2013
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-05-07
Last Modified:2017-11-07
Downloads:0

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