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Correlations between radiographic assessments and MRI features of knee osteoarthritis - a cross-sectional study

Citation

Gudbergsen, H and Lohmander, LS and Jones, G and Christensen, R and Bartels, EM and Danneskiold-Samsoe, B and Bliddal, H and Boesen, M, Correlations between radiographic assessments and MRI features of knee osteoarthritis - a cross-sectional study, Osteoarthritis and Cartilage, 21, (4) pp. 535-543. ISSN 1063-4584 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Elsevier Ltd on behalf of Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2012.12.010

Abstract

Objectives: To assess correlations between Kellgren & Lawrence (KL) gradings, minimum joint space width (mJSW) measurements and the Boston Leeds Osteoarthritis Knee Score (BLOKS) within a cohort of obese patients with knee osteoarthritis (KOA). Methods: 192 Participants were recruited from an outpatient clinic (ClinicalTrials.gov: NCT00655941). Inclusion criteria were age ≥50 years, body mass index (BMI) ≥30 kg/m2 plus symptomatic and verified KOA. 1.5 T magnetic resonance imaging (MRI) scans were assessed using BLOKS and bi-plane radiography by mJSW and KL. Statistics used were Spearman rank correlation coefficients. Results: The average patient was 63 years of age, female and had a BMI of 37. KL gradings correlated to cartilage damage, bone marrow lesions and meniscus pathology (r = 0.15-0.76) and similar results were found for the relationship between BLOKS and mJSW. BLOKS assessed knee joint pathology co-segregated with compartment and grade specific KL (P < 0.0001). BLOKS variables were statistically significant correlated, particularly in the medial tibiofemoral compartment (r = 0.42-0.80). Adjusting for age, gender and BMI did not alter these associations. Conclusion: Extensive pathological damage is present even in mild radiographic KOA and BLOKS gradings and KL scores increase together. Analyses of compartment specific KL scores revealed differences in their relationship to the assessed MRI variables. Our study displays the segregation of MRI gradings with respect to location and level of radiographic scores, reveals a high inter-dependency of MRI-assessed structures, and describes some redundancy of specific BLOKS variables. © 2013.

Item Details

Item Type:Refereed Article
Keywords:MRI; Knee osteoarthritis; Radiography; X-ray; KOA; Kellgren & Lawrence; KL; BLOKS
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
ID Code:84266
Year Published:2013
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-05-01
Last Modified:2017-11-02
Downloads:0

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