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Sixty years young: The diverse biological activities of metal polypyridyl complexes pioneered by Francis P. Dwyer
Sixty years ago, the Australian chemist Francis P. Dwyer pioneered the use of ruthenium polypyridyl complexes as biologically active compounds. These chemically inert and configurationally stable complexes revealed an astonishing range of interesting biological activities, such as the inhibition of the enzyme acetylcholinesterase, anti-cancer activity in vivo, and bacteriostatic/bacteriocidal action. This review commemorates the sixtieth anniversary of Dwyer and co-workers’ landmark 1952 publication, summarises their broader achievements in biological inorganic chemistry, and discusses the contribution of this work to the development of modern biological and medicinal inorganic chemistry.
History
Publication title
Australian Journal of Chemistry: An International Journal for Chemical ScienceVolume
65Issue
9Pagination
1325-1332ISSN
0004-9425Department/School
School of Natural SciencesPublisher
CSIRO PublishingPlace of publication
150 Oxford St, Po Box 1139, Collingwood, Australia, Victoria, 3066Rights statement
Copyright 2012 CSIRORepository Status
- Restricted