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Sixty years young: The diverse biological activities of metal polypyridyl complexes pioneered by Francis P. Dwyer

Citation

Kilah, NL and Meggers, E, Sixty years young: The diverse biological activities of metal polypyridyl complexes pioneered by Francis P. Dwyer, Australian Journal of Chemistry: An International Journal for Chemical Science, 65, (9) pp. 1325-1332. ISSN 0004-9425 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 CSIRO

DOI: doi:10.1071/CH12275

Abstract

Sixty years ago, the Australian chemist Francis P. Dwyer pioneered the use of ruthenium polypyridyl complexes as biologically active compounds. These chemically inert and configurationally stable complexes revealed an astonishing range of interesting biological activities, such as the inhibition of the enzyme acetylcholinesterase, anti-cancer activity in vivo, and bacteriostatic/bacteriocidal action. This review commemorates the sixtieth anniversary of Dwyer and co-workers’ landmark 1952 publication, summarises their broader achievements in biological inorganic chemistry, and discusses the contribution of this work to the development of modern biological and medicinal inorganic chemistry.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Inorganic Chemistry
Research Field:Bioinorganic Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Kilah, NL (Dr Nathan Kilah)
ID Code:84229
Year Published:2012
Web of Science® Times Cited:36
Deposited By:Chemistry
Deposited On:2013-04-30
Last Modified:2017-10-25
Downloads:0

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