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Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study


Laslett, LL and Quinn, S and Burgess, JR and Parameswaran, V and Winzenberg, TM and Jones, G and Ding, C, Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study, Annals of the Rheumatic Diseases, 73, (4) pp. 697-703. ISSN 1468-2060 (2014) [Refereed Article]


Copyright Statement

Copyright 2013 the authors

DOI: doi:10.1136/annrheumdis-2012-202831


Background: Vitamin D is important for bone, cartilage and muscle function but there are few studies on its association with joint pain.

Objective To investigate whether serum vitamin D predicts change in knee and hip pain in older adults.

Methods Longitudinal population-based cohort study of randomly selected older adults (n=769) aged 5080 years (mean 62 years); 50% were male. Serum 25-hydroxyvitamin D (25-OHD) was assessed at baseline by radioimmunoassay, and pain at baseline, 2.6 and/or 5 years using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire. We used linear regression with adjustment for age, sex, body mass index and season, then further adjusted for potential structural mechanisms (radiographic osteoarthritis, bone marrow lesions, chondral defects and muscle strength).

Results Mean total knee WOMAC score was 3.2 (range 039). 4.2% of participants had moderate vitamin D deficiency at baseline (25-OHD 12.525 nmol/l). 25-OHD <25 nmol/l predicted change in knee pain (using total WOMAC score) over 5 years (β=2.41, p=0.002) with a similar effect size for hip pain over 2.4 years (β=2.20, p=0.083). Results were consistent within pain subscales, and the association was independent of demographic, anthropometric and structural covariates. No association was present when 25-OHD was analysed as a continuous measure.

Conclusions Moderate vitamin D deficiency independently predicts incident, or worsening of, knee pain over 5 years and, possibly, hip pain over 2.4 years. Therefore correcting moderate vitamin deficiency may attenuate worsening of knee or hip pain in elderly people but giving supplements to those with a higher 25-OHD level is unlikely to be effective.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, knee, pain, vitamin D deficiency
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Burgess, JR (Professor John Burgess)
UTAS Author:Winzenberg, TM (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:84192
Year Published:2014 (online first 2013)
Web of Science® Times Cited:50
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-04-29
Last Modified:2017-11-02
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