eCite Digital Repository

Association of weight gain with incident knee pain, stiffness, and functional difficulties: A longitudinal study


Tanamas, SK and Wluka, AE and Davies-Tuck, M and Wang, Y and Strauss, BJ and Proietto, J and Dixon, JB and Jones, G and Forbes, A and Cicuttini, FM, Association of weight gain with incident knee pain, stiffness, and functional difficulties: A longitudinal study, Arthritis Care and Research, 65, (1) pp. 34-43. ISSN 2151-464X (2013) [Refereed Article]

Copyright Statement

Copyright 2013 American College of Rheumatology

DOI: doi:10.1002/acr.21745


Objective To examine the longitudinal association between significant weight change and change in knee symptoms (pain, stiffness, and function), and to determine whether the effects differ in those who are obese and those with osteoarthritis (OA). Methods Two hundred fifty subjects ranging from normal weight to obese (body mass index range 16.9-59.1 kg/m2) and no significant musculoskeletal disease were recruited from the general community and weight loss clinics and organizations. Seventy-eight percent were followed at ∼2 years. Weight, height, and knee symptoms (using the Western Ontario and McMaster Universities Osteoarthritis Index) were assessed at baseline and followup. Any weight loss methods were recorded. Results Thirty percent of subjects lost ≥5% of baseline weight, 56% of subjects' weight remained stable (loss or gain of <5% of baseline weight), and 14% of subjects gained ≥5% of baseline weight. Using estimated marginal means, weight gain was associated with worsening pain (mean 27.1 mm; 95% confidence interval [95% CI] -1.1, 55.2), stiffness (mean 18.4 mm; 95% CI 1.5, 35.3), and function (mean 99.3 mm; 95% CI 4.0, 194.6) compared to stable weight. Weight loss was associated with reduced pain (mean -22.4 mm; 95% CI -44.4, -0.3), stiffness (mean -15.3 mm; 95% CI -28.50, -2.0), and function (mean -73.2 mm; 95% CI -147.9, 1.3) compared to stable weight. Conclusion Weight gain was associated with adverse effects on knee symptoms, particularly in those who are obese and who have OA. Although losing weight is potentially beneficial for symptom improvement, the effects were more modest. Avoiding weight gain is important in managing knee symptoms. Copyright © 2013 by the American College of Rheumatology.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:84100
Year Published:2013
Web of Science® Times Cited:35
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-04-17
Last Modified:2017-11-02

Repository Staff Only: item control page