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Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling

Citation

Young, KM and Psachoulia, K and Tripathi, RB and Dunn, SJ and Cossell, L and Attwell, D and Tohyama, K and Richardson, WD, Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling, Neuron, 77, (5) pp. 873-885. ISSN 0896-6273 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Elsevier Inc.

DOI: doi:10.1016/j.neuron.2013.01.006

Abstract

Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood. It is not known whether adult-born OLs ensheath previously unmyelinated axons or remodel existing myelin. We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated. Even there, all OPs were dividing and generating new OLs and myelin at a rate higher than can be explained by first-time myelination of naked axons. We conclude that adult-born OLs in the optic nerve are engaged in myelin remodeling, either replacing OLs that die in service or intercalating among existing myelin sheaths. The latter would predict that average internode length should decrease with age. Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Young, KM (Dr Kaylene Young)
ID Code:84094
Year Published:2013
Web of Science® Times Cited:233
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-04-17
Last Modified:2017-11-07
Downloads:0

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