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Effect of in vivo exposure to allogeneic cells upon subsequent in vitro T cell responses and upon allograft rejection
Citation
Cooley, MA, Effect of in vivo exposure to allogeneic cells upon subsequent in vitro T cell responses and upon allograft rejection, Scandinavian Journal of Immunology, 7, (5) pp. 371-80. ISSN 0300-9475 (1978) [Refereed Article]
DOI: doi:10.1111/j.1365-3083.1978.tb00467.x
Abstract
The effect of intravenous injection of 10(6) BALB/c spleen cells into C57B1/6J recipients was assayed by both mixed lymphocyte culture (MLC) of recipient lymphocytes, and by grafting donor (BALB/c) thyroids into recipient mice. It was observed that a single intravenous injection produced depression of proliferative and cytotoxic T cell responses in MLC of spleen, lymph node and peripheral blood lymphocytes of the recipients. This effect was specific for the sensitizing genotype (MLC of recipient and third-party CBA/H lymphocytes was unaffected), and persisted for several days after sensitization. The pattern of this diminished response suggested that the effect was due to a combination of recruitment of reactive lymphocytes from peripheral lymphoid populations, and the generation of alloantigen (H-2?)-specific suppressor T cells in the spleen. In contrast to these findings in vitro, a similar sensitization led only to accelerated rejection of thyroid allografts in vivo.
Item Details
Item Type: | Refereed Article |
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Research Division: | Medical and Health Sciences |
Research Group: | Immunology |
Research Field: | Cellular Immunology |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Infectious Diseases |
UTAS Author: | Cooley, MA (Associate Professor Margaret Cooley) |
ID Code: | 83902 |
Year Published: | 1978 |
Web of Science® Times Cited: | 8 |
Deposited By: | Medicine |
Deposited On: | 2013-03-26 |
Last Modified: | 2013-03-26 |
Downloads: | 0 |
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