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Multiple pathways of T-T interaction in the generation of cytotoxic T lymphocytes to alloantigens


Corley, RB and Switzer, KA and Hudson, DE and Cooley, MA, Multiple pathways of T-T interaction in the generation of cytotoxic T lymphocytes to alloantigens, The Journal of Experimental Medicine, 151, (5) pp. 1125-38. ISSN 0022-1007 (1980) [Refereed Article]

DOI: doi:10.1084/jem.151.5.1125


The interaction of T helper (Th) cells with syngeneic and allogeneic cytotoxic T lymphocyte precursors (CTL.P) has been investigated. Unprimed and mixed lymphocyte culture-primed peripheral T cells were used as a source of Th. Thymocytes, which depend upon exogenous Th cells for activation, were used as a source of cytotoxic precursors. Data is presented that demonstrates that at least two pathways of T-T interaction can lead to the activation of cytotoxic lymphocytes. The first is an allogeneic effect, in which Th cells recognize and respond to alloantigens expressed on CTL.P. The second is the interaction of Th cells with syngeneic CTL.P, in which both cell types are thought to respond to alloantigens on stimulator cells. The latter interaction can be shown to be restricted by H-2-linked determinants when primed Th cells are used and allogeneic effects against thymocytes are minimized. Restricted interactions between unprimed Th cells and thymocyte CTL.P have never been observed. Mechanisms that may explain the difference between the interaction of unprimed and primed Th cells with CTL.P are discussed.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Cooley, MA (Associate Professor Margaret Cooley)
ID Code:83899
Year Published:1980
Web of Science® Times Cited:17
Deposited By:Medicine
Deposited On:2013-03-26
Last Modified:2013-03-26

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