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Studies on the lymphocytosis induced by pertussis toxin

Citation

Mu, HH and Cooley, MA and Sewell, WA, Studies on the lymphocytosis induced by pertussis toxin, Immunology and Cell Biology, 72, (3) pp. 267-70. ISSN 0818-9641 (1994) [Refereed Article]

DOI: doi:10.1038/icb.1994.40

Abstract

Pertussis toxin (PT), from Bordetella pertussis, causes lymphocytosis and increased IL-4 and IgE secretion. The lymphocytosis is associated with impaired entry of lymphocytes into lymph nodes. The dose response of PT on IL-4 secretion was found to be similar to those for lymphocytosis and IgE production. These findings are consistent with the possibility that increased IL-4 production by PT may be related to its effect on lymphocyte circulation. The possibility that PT may selectively influence the entry into lymph nodes of subsets identified with CD45RB, CD4 or CD8 was tested by assessing the phenotype of lymph node cells. PT had no significant effect on the proportion of cells with these markers, either in unimmunized or in immunized mice. These findings indicate that PT does not selectively impair entry of these lymphocyte subsets into lymph nodes.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Cooley, MA (Associate Professor Margaret Cooley)
ID Code:83865
Year Published:1994
Web of Science® Times Cited:4
Deposited By:Medicine (Discipline)
Deposited On:2013-03-26
Last Modified:2013-03-26
Downloads:0

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