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Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4

journal contribution
posted on 2023-05-17, 16:53 authored by Li, Y, Li, L, Wadley, R, Reddel, SW, Qi, JC, Archis, C, Clark, E, Cooley, M, Kouts, S, Naif, HM, Alali, M, Cunningham, A, Wong, GW, Stevens, RL, Krilis, SA
A population of metachromatic cells with mast cell (MC) and basophil features was identified recently in the peripheral blood of patients with several allergic disorders. This study now shows that these metachromatic cells express on their surface the high-affinity IgE receptor (FcepsilonRI), CD4, and the chemokine receptors CCR3, CCR5, and CXCR4, but not the T-cell surface protein CD3 and the monocyte/macrophage surface protein CD68. This population of MCs/basophils can be maintained ex vivo for at least 2 weeks, and a comparable population of cells can be generated in vitro from nongranulated hematopoietic CD3(-)/CD4(+)/CD117(-) progenitors. Both populations of MCs/basophils are susceptible to an M-tropic strain of human immunodeficiency virus 1 (HIV-1). Finally, many patients with acquired immunodeficiency syndrome have HIV-1-infected MCs/basophils in their peripheral blood. Although it is well known that HIV-1 can infect CD4(+) T cells and monocytes, this finding is the first example of a human MC or basophil shown to be susceptible to the retrovirus

History

Publication title

Blood

Volume

97

Issue

11

Pagination

3484 - 3490

ISSN

0006-4971

Department/School

Tasmanian School of Medicine

Publisher

Amer Soc Hematology

Place of publication

1900 M Street. Nw Suite 200, Washington, USA, Dc, 20036

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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