Quinn, CR and Harris, A and Felmingham, KL and Boyce, P and Kemp, A, The impact of depression heterogeneity on cognitive control in major depressive disorder, Australian and New Zealand Journal of Psychiatry, 46, (11) pp. 1079-1088. ISSN 0004-8674 (2012) [Refereed Article]
Copyright 2012 The Royal Australian and New Zealand College of Psychiatrists
Methods: Neuropsychological function across a range of cognitive control tasks was examined in melancholic (n = 65) and non-melancholic depressed patients (n = 59) relative to controls (n = 124). The relationship between subtype (melancholia vs non-melancholia) and anxiety was also examined.
Results: Melancholia was characterised by attention and working memory deficits typically associated with the dorsolateral prefrontal cortex, while non-melancholia was characterised by verbal memory recall deficits indicative of left frontal lobe and medial temporal lobe function. The severity of anxious arousal and psychomotor disturbance contributed to cognitive impairment more than the severity of depression symptoms and anxious apprehension.
Conclusions: Findings highlight a differential impact of depression subtype and severity, and suggest that anxious arousal and psychomotor disturbance may contribute to poorer performance on neuropsychological tasks associated with dorsolateral prefrontal cortex function.
|Item Type:||Refereed Article|
|Keywords:||cognitive control, depression, executive function, neuropsychology|
|Research Division:||Psychology and Cognitive Sciences|
|Research Field:||Health, Clinical and Counselling Psychology|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified|
|Author:||Felmingham, KL (Professor Kim Felmingham)|
|Web of Science® Times Cited:||11|
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