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The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study
Citation
Outhred, T and Das, P and Dobson-Stone, C and Griffiths, K and Felmingham, KL and Bryant, RA and Malhi, G and Kemp, AH, The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study, Brain and Behavior, 2, (6) pp. 778-788. ISSN 2162-3279 (2012) [Refereed Article]
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Copyright Statement
Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/
DOI: doi:10.1002/brb3.99
Abstract
An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms
has been implicated in the structure of rostral anterior cingulate cortex
(rACC) and amygdala (AMY): key regions associated with emotion processing.
However, a functional epistasis of 5-HTTLPR and BDNF Val66Met on overt
emotion processing has yet to be determined. Twenty-eight healthy, Caucasian
female participants provided saliva samples for genotyping and underwent
functional magnetic resonance imaging (fMRI) during which an emotion processing
protocol were presented. Confirming the validity of this protocol, we
observed blood oxygen level–dependent (BOLD) activity consistent with fMRI
meta-analyses on emotion processing. Region-of-interest analysis of the rACC
and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an
interaction of 5-HTTLPR and BDNF Val66Met. The effect of the BDNF
Met66 allele was dependent on 5-HTTLPR alleles, such that participants with
S and Met alleles had the greatest rACC and AMY activation during the presentation
of emotional images relative to other genetic groupings. Increased
activity in these regions was interpreted as increased reactivity to emotional
stimuli, suggesting that those with S and Met alleles are more reactive to emotional
stimuli relative to other groups. Although limited by a small sample,
this study contributes novel and preliminary findings relating to a functional
epistasis of the 5-HTTLPR and BDNF Val66Met genes in emotion processing
and provides guidance on appropriate methods to determine genetic epistasis
in fMRI.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | 5HTTLPR, BDNF, emotion processing, epistatis, fMRI |
| Research Division: | Psychology and Cognitive Sciences |
| Research Group: | Psychology |
| Research Field: | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified |
| Author: | Felmingham, KL (Professor Kim Felmingham) |
| ID Code: | 83598 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Psychology |
| Deposited On: | 2013-03-19 |
| Last Modified: | 2014-11-27 |
| Downloads: | 224 View Download Statistics |
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