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The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study

Citation

Outhred, T and Das, P and Dobson-Stone, C and Griffiths, K and Felmingham, KL and Bryant, RA and Malhi, G and Kemp, AH, The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study, Brain and Behavior, 2, (6) pp. 778-788. ISSN 2162-3279 (2012) [Refereed Article]


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Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.1002/brb3.99

Abstract

An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion processing. However, a functional epistasis of 5-HTTLPR and BDNF Val66Met on overt emotion processing has yet to be determined. Twenty-eight healthy, Caucasian female participants provided saliva samples for genotyping and underwent functional magnetic resonance imaging (fMRI) during which an emotion processing protocol were presented. Confirming the validity of this protocol, we observed blood oxygen level–dependent (BOLD) activity consistent with fMRI meta-analyses on emotion processing. Region-of-interest analysis of the rACC and AMY revealed main effects of 5-HTTLPR and BDNF Val66Met, and an interaction of 5-HTTLPR and BDNF Val66Met. The effect of the BDNF Met66 allele was dependent on 5-HTTLPR alleles, such that participants with S and Met alleles had the greatest rACC and AMY activation during the presentation of emotional images relative to other genetic groupings. Increased activity in these regions was interpreted as increased reactivity to emotional stimuli, suggesting that those with S and Met alleles are more reactive to emotional stimuli relative to other groups. Although limited by a small sample, this study contributes novel and preliminary findings relating to a functional epistasis of the 5-HTTLPR and BDNF Val66Met genes in emotion processing and provides guidance on appropriate methods to determine genetic epistasis in fMRI.

Item Details

Item Type:Refereed Article
Keywords:5HTTLPR, BDNF, emotion processing, epistatis, fMRI
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:83598
Year Published:2012
Web of Science® Times Cited:12
Deposited By:Psychology
Deposited On:2013-03-19
Last Modified:2014-11-27
Downloads:224 View Download Statistics

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