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The brain-derived neurotophic factor Val66Met polymorphism predicts response to exposure therapy in Posttraumatic Stress Disorder

Citation

Felmingham, KL and Dobson-Stone, C and Schofield, PR and Quirk, GJ and Bryant, RA, The brain-derived neurotophic factor Val66Met polymorphism predicts response to exposure therapy in Posttraumatic Stress Disorder, Biological Psychiatry, 73, (11) pp. 1059-1063. ISSN 0006-3223 (2013) [Refereed Article]

Copyright Statement

Copyright 2012 Society of Biological Psychiatry

DOI: doi:10.1016/j.biopsych.2012.10.033

Abstract

Background: The most effective treatment for posttraumatic stress disorder (PTSD) is exposure therapy, which aims to facilitate extinction of conditioned fear. Recent evidence suggests that brain-derived neurotrophic factor (BDNF) facilitates extinction learning. This study assessed whether the Met-66 allele of BDNF, which results in lower activity-dependent secretion, predicts poor response to exposure therapy in PTSD. Methods: Fifty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva to extract genomic DNA to determine their BDNF Val66Met genotype (30 patients with the Val/Val BDNF allele, 25 patients with the Met-66 allele). We examined whether BDNF genotype predicted reduction in PTSD severity following exposure therapy. Results: Analyses revealed poorer response to exposure therapy in the PTSD patients with the Met-66 allele of BDNF compared with patients with the Val/Val allele. Pretreatment Clinician Administered PTSD Scale severity and BDNF Val66Met polymorphism predicted response to exposure therapy using hierarchical regression. Conclusions: This study provides the first evidence that the BDNF Val66Met genotype predicts response to cognitive behavior therapy in PTSD and is in accord with evidence that BDNF facilitates extinction learning.

Item Details

Item Type:Refereed Article
Keywords:BDNF, PTSD, CBT, fear extinction, fMRI
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:83590
Year Published:2013 (online first 2012)
Web of Science® Times Cited:57
Deposited By:Psychology
Deposited On:2013-03-19
Last Modified:2015-07-28
Downloads:0

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