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Effects of Filtration on the Presence of Particulate and Oxycodone Content of Injections Prepared from Crushed OxyContin® Tablets

Citation

Patel, PK and Patel, RP and Brandon, S and McLean, S and Bruno, R and de Graaff, B, Effects of Filtration on the Presence of Particulate and Oxycodone Content of Injections Prepared from Crushed OxyContin® Tablets, Current Drug Safety, 7, (3) pp. 218-224. ISSN 1574-8863 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Bentham Science Publishers

DOI: doi:10.2174/157488612803251298

Abstract

It is common for injecting drug users (IDU) to prepare injections by crushing tablets which are not designed for parental administration. The injection of insoluble tablet excipients can lead to serious local and systemic medical complications. The aim of the study was to investigate the effectiveness of various types of filters in removing harmful insoluble particles from the injections prepared using crushed oxycodone tablets. Injections were prepared from a sustained-release oxycodone tablet formulation. The filtration of tablet extracts was carried out following procedures used by IDU using makeshift filter and commercially available filters. Particulate contamination and oxycodone content were analysed using light microscopy and spectrophotometer. Unfiltered extracts contained hundreds of thousands of particles of sufficient size to cause harms. Cigarette filters removed large particles but failed to remove small particles. The combination of cigarette filter and syringe filter (0.45 ým or 0.22 ým) reduced the particle count by 90 - 95%. A double membrane syringe filter (0.8/0.2 ým) removed more than 99% of the particles. Recovery of oxycodone was more than 95% with the tested syringe filters. Particulate contamination in injections prepared from crushed tablets can be effectively removed using a combination process of cigarette filter and syringe filters, or a 0.8/0.2 ým syringe filter. Compared to other filters, the 0.8/0.2 ým syringe filter did not block, the filtration was quick and easy to perform, and did not retain oxycodone. The use of a 0.8/0.2 ým syringe filter can provide an important harm reduction measure for IDU.

Item Details

Item Type:Refereed Article
Keywords:oxycontin, injection, filtration, harm reduction
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Public Health and Health Services not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Substance Abuse
Author:Patel, PK (Mr Pankajkumar Patel)
Author:Patel, RP (Dr Rahul Patel)
Author:Brandon, S (Mrs Susan Brandon)
Author:McLean, S (Professor Stuart McLean)
Author:Bruno, R (Associate Professor Raimondo Bruno)
Author:de Graaff, B (Ms Barbara de Graaff)
ID Code:83578
Year Published:2012
Web of Science® Times Cited:5
Deposited By:Psychology
Deposited On:2013-03-19
Last Modified:2017-11-02
Downloads:0

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