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Seven-Membered Rings
Citation
Ryan, JH and Hyland, C and Meyer, AG and Smith, JA and Yin, J, Seven-Membered Rings, Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 493-536. ISBN 978-0-08-096807-0 (2012) [Research Book Chapter]
Copyright Statement
Copyright 2012 Elsevier
DOI: doi:10.1016/B978-0-08-096807-0.00016-6
Abstract
The synthesis of iboga alkaloids, containing an isoquinuclidine ring, fused with an indoloazepine ring system, has been reviewed. There continues to
be strong interest in seven-membered heterocycles containing one, two, or three
of the heteroatoms N, O, or S. The majority of the literature relates to aromatic fused systems containing at least one N and is driven by the search for new biologically active molecules. New synthetic methods of interest include transition metal-catalyzed, multicomponent, dipolar cycloaddition, ring expansion, and electrocyclization processes. There is increasing recognition that seven-membered rings are useful tools for restricting the conformation of bioactive compounds, and certain systems exhibit atropisomerism which in turn can affect their reactivity and biological activity.
Item Details
| Item Type: | Research Book Chapter |
|---|---|
| Research Division: | Chemical Sciences |
| Research Group: | Organic Chemistry |
| Research Field: | Organic Chemical Synthesis |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Chemical Sciences |
| Author: | Hyland, C (Dr Chris Hyland) |
| Author: | Smith, JA (Associate Professor Jason Smith) |
| Author: | Yin, J (Mr JieXiang Yin) |
| ID Code: | 83410 |
| Year Published: | 2012 |
| Deposited By: | Chemistry |
| Deposited On: | 2013-03-13 |
| Last Modified: | 2015-04-27 |
| Downloads: | 1 View Download Statistics |
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