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Seven-Membered Rings
chapter
posted on 2023-05-22, 13:59 authored by Ryan, JH, Hyland, C, Meyer, AG, Jason SmithJason Smith, Yin, JThe synthesis of iboga alkaloids, containing an isoquinuclidine ring, fused with an indoloazepine ring system, has been reviewed. There continues to be strong interest in seven-membered heterocycles containing one, two, or three of the heteroatoms N, O, or S. The majority of the literature relates to aromatic fused systems containing at least one N and is driven by the search for new biologically active molecules. New synthetic methods of interest include transition metal-catalyzed, multicomponent, dipolar cycloaddition, ring expansion, and electrocyclization processes. There is increasing recognition that seven-membered rings are useful tools for restricting the conformation of bioactive compounds, and certain systems exhibit atropisomerism which in turn can affect their reactivity and biological activity.
History
Publication title
Progress in Heterocyclic ChemistryVolume
24Editors
GW Gribble, JA JoulePagination
493-536ISBN
978-0-08-096807-0Department/School
School of Natural SciencesPublisher
ElsevierPlace of publication
Oxford, United KingdomExtent
17Rights statement
Copyright 2012 ElsevierRepository Status
- Restricted