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Seven-Membered Rings
Citation
Ryan, JH and Hyland, C and Meyer, AG and Smith, JA and Yin, J, Seven-Membered Rings, Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 493-536. ISBN 978-0-08-096807-0 (2012) [Research Book Chapter]
Copyright Statement
Copyright 2012 Elsevier
DOI: doi:10.1016/B978-0-08-096807-0.00016-6
Abstract
The synthesis of iboga alkaloids, containing an isoquinuclidine ring, fused with an indoloazepine ring system, has been reviewed. There continues to
be strong interest in seven-membered heterocycles containing one, two, or three
of the heteroatoms N, O, or S. The majority of the literature relates to aromatic fused systems containing at least one N and is driven by the search for new biologically active molecules. New synthetic methods of interest include transition metal-catalyzed, multicomponent, dipolar cycloaddition, ring expansion, and electrocyclization processes. There is increasing recognition that seven-membered rings are useful tools for restricting the conformation of bioactive compounds, and certain systems exhibit atropisomerism which in turn can affect their reactivity and biological activity.
Item Details
Item Type: | Research Book Chapter |
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Research Division: | Chemical Sciences |
Research Group: | Organic chemistry |
Research Field: | Organic chemical synthesis |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Hyland, C (Dr Chris Hyland) |
UTAS Author: | Smith, JA (Associate Professor Jason Smith) |
UTAS Author: | Yin, J (Mr JieXiang Yin) |
ID Code: | 83410 |
Year Published: | 2012 |
Deposited By: | Chemistry |
Deposited On: | 2013-03-13 |
Last Modified: | 2017-10-25 |
Downloads: | 1 View Download Statistics |
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