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Seven-Membered Rings


Ryan, JH and Hyland, C and Meyer, AG and Smith, JA and Yin, J, Seven-Membered Rings, Progress in Heterocyclic Chemistry, Elsevier, GW Gribble, JA Joule (ed), Oxford, United Kingdom, pp. 493-536. ISBN 978-0-08-096807-0 (2012) [Research Book Chapter]

Copyright Statement

Copyright 2012 Elsevier

DOI: doi:10.1016/B978-0-08-096807-0.00016-6


The synthesis of iboga alkaloids, containing an isoquinuclidine ring, fused with an indoloazepine ring system, has been reviewed. There continues to be strong interest in seven-membered heterocycles containing one, two, or three of the heteroatoms N, O, or S. The majority of the literature relates to aromatic fused systems containing at least one N and is driven by the search for new biologically active molecules. New synthetic methods of interest include transition metal-catalyzed, multicomponent, dipolar cycloaddition, ring expansion, and electrocyclization processes. There is increasing recognition that seven-membered rings are useful tools for restricting the conformation of bioactive compounds, and certain systems exhibit atropisomerism which in turn can affect their reactivity and biological activity.

Item Details

Item Type:Research Book Chapter
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Hyland, C (Dr Chris Hyland)
UTAS Author:Smith, JA (Associate Professor Jason Smith)
UTAS Author:Yin, J (Mr JieXiang Yin)
ID Code:83410
Year Published:2012
Deposited By:Chemistry
Deposited On:2013-03-13
Last Modified:2017-10-25
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