In this paper, by injecting a SDS micellar plug before the sample prepared in aqueous organic solvents, we show the on-line sample preconcentration of cations via micelle to solvent stacking (MSS) using solvents of as low as 30%. This extends the choice of stacking techniques to includemoderate amounts of organic solvent in the sample. The approach is akin to in-line solid phase extraction where the micellar plug acted as a transient micellar phase extractor. Basic studies were conducted (e.g. type and amount of organic solvent in the sample). The calculated sensitivity enhancement factors based on LOD obtained for the six test antipsychotic drugs were from 41 to 68. The peak signals were linear (R² >0.99) from 0.2 to 10.0 µg/mL. The intraday and interday reproducibility (n = 10) for migration time, peak height, and corrected peak area were from 0.2 to 13.6%. The technique was also tested on spiked wastewater sample with minimal sample treatment (i.e. dilution and centrifugation).

Item Type:	Refereed Article
Keywords:	antipsychotic drugs, capillary electrophoresis, micelle to solvent stacking, on-line sample concentration, organic solvent
Research Division:	Chemical Sciences
Research Group:	Analytical Chemistry
Research Field:	Separation Science
Objective Division:	Expanding Knowledge
Objective Group:	Expanding Knowledge
Objective Field:	Expanding Knowledge in the Chemical Sciences
Author:	Quirino, JP (Associate Professor Lito Quirino)
Author:	Aranas, AT (Miss T Aranas)
ID Code:	83359
Year Published:	2012
Web of Science® Times Cited:	16
Deposited By:	Austn Centre for Research in Separation Science
Deposited On:	2013-03-12
Last Modified:	2013-04-23
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