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Methylglyoxal, cognitive function and cerebral atrophy in older people


Srikanth, V and Westcott, B and Forbes, J and Phan, TG and Beare, R and Venn, A and Pearson, S and Greenaway, T and Parameswaran, V and Munch, G, Methylglyoxal, cognitive function and cerebral atrophy in older people, Journals of Gerontology. Series A, Biological sciences and medical sciences., 68, (1) pp. 68-73. ISSN 1079-5006 (2013) [Refereed Article]

Copyright Statement

Copyright 2012 The Authors

DOI: doi:10.1093/gerona/gls100


BACKGROUND: The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people. METHODS: Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use. RESULTS: There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory ( = -.12, 95% confidence interval: -0.22, -0.02, p = .02) and executive function, the latter being greater among those with a history of stroke (MGO ~ stroke = .48, 95% confidence interval: 0.17, 0.79, p = .002). Greater MGO was associated with lower grey matter volume ( = -6.42, 95% confidence interval -11.82, -1.11, p = .02) but not with white matter volume, white matter lesion volume, or hippocampal volume. CONCLUSIONS: These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people.

Item Details

Item Type:Refereed Article
Keywords:cognitive functioning, cerebral atrophy
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Pearson, S (Dr Sue Pearson)
ID Code:83240
Year Published:2013
Funding Support:National Health and Medical Research Council (436797)
Web of Science® Times Cited:69
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-03-06
Last Modified:2014-04-16

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