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Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial

Citation

Edwards, LM and Kemp, GJ and Dwyer, RM and Walls, JT and Fuller, H and Smith, SR and Earnest, CP, Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial, Scientific Reports, 3 Article 1182. ISSN 2045-2322 (2013) [Refereed Article]


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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. http://creativecommons.org/licenses/by-nc-nd/3.0/

DOI: doi:10.1038/srep01182

Abstract

We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.

Item Details

Item Type:Refereed Article
Keywords:physiology, biochemistry, systems biology, skeletal muscle
Research Division:Biological Sciences
Research Group:Physiology
Research Field:Physiology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Edwards, LM (Dr Lindsay Edwards)
Author:Dwyer, RM (Dr Renee Dwyer)
Author:Walls, JT (Professor Justin Walls)
Author:Fuller, H (Mr Huddy Fuller)
ID Code:83179
Year Published:2013
Web of Science® Times Cited:5
Deposited By:Medicine (Discipline)
Deposited On:2013-03-05
Last Modified:2017-11-07
Downloads:210 View Download Statistics

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