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Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial
Citation
Edwards, LM and Kemp, GJ and Dwyer, RM and Walls, JT and Fuller, H and Smith, SR and Earnest, CP, Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial, Scientific Reports, 3 Article 1182. ISSN 2045-2322 (2013) [Refereed Article]
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Copyright Statement
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. http://creativecommons.org/licenses/by-nc-nd/3.0/
Abstract
We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | physiology, biochemistry, systems biology, skeletal muscle |
| Research Division: | Biological Sciences |
| Research Group: | Physiology |
| Research Field: | Physiology not elsewhere classified |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Medical and Health Sciences |
| Author: | Edwards, LM (Dr Lindsay Edwards) |
| Author: | Dwyer, RM (Dr Renee Dwyer) |
| Author: | Walls, JT (Professor Justin Walls) |
| Author: | Fuller, H (Mr Huddy Fuller) |
| ID Code: | 83179 |
| Year Published: | 2013 |
| Web of Science® Times Cited: | 5 |
| Deposited By: | Medicine (Discipline) |
| Deposited On: | 2013-03-05 |
| Last Modified: | 2017-11-07 |
| Downloads: | 224 View Download Statistics |
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