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We acquired ³¹P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO₂max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO₂ and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO₂max (r² = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.

Item Type:	Refereed Article
Keywords:	physiology, biochemistry, systems biology, skeletal muscle
Research Division:	Biological Sciences
Research Group:	Physiology
Research Field:	Physiology not elsewhere classified
Objective Division:	Expanding Knowledge
Objective Group:	Expanding Knowledge
Objective Field:	Expanding Knowledge in the Medical and Health Sciences
UTAS Author:	Edwards, LM (Dr Lindsay Edwards)
UTAS Author:	Dwyer, RM (Dr Renee Ross)
UTAS Author:	Walls, JT (Professor Justin Walls)
UTAS Author:	Fuller, H (Mr Huddy Fuller)
ID Code:	83179
Year Published:	2013
Web of Science® Times Cited:	7
Deposited By:	Medicine
Deposited On:	2013-03-05
Last Modified:	2017-11-07
Downloads:	289 View Download Statistics