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Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial

Citation

Edwards, LM and Kemp, GJ and Dwyer, RM and Walls, JT and Fuller, HJ and Smith, SR and Earnest, CP, Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial, Scientific Reports, 3 Article 1182. ISSN 2045-2322 (2013) [Refereed Article]


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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. http://creativecommons.org/licenses/by-nc-nd/3.0/

DOI: doi:10.1038/srep01182

Abstract

We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.

Item Details

Item Type:Refereed Article
Keywords:physiology, biochemistry, systems biology, skeletal muscle
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Zoology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Edwards, LM (Dr Lindsay Edwards)
UTAS Author:Dwyer, RM (Dr Renee Ross)
UTAS Author:Walls, JT (Professor Justin Walls)
UTAS Author:Fuller, HJ (Dr Huddy Fuller)
ID Code:83179
Year Published:2013
Web of Science® Times Cited:9
Deposited By:Medicine
Deposited On:2013-03-05
Last Modified:2017-11-07
Downloads:340 View Download Statistics

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