eCite Digital Repository
Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial
Citation
Edwards, LM and Kemp, GJ and Dwyer, RM and Walls, JT and Fuller, HJ and Smith, SR and Earnest, CP, Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial, Scientific Reports, 3 Article 1182. ISSN 2045-2322 (2013) [Refereed Article]
 | PDF 511Kb |
Copyright Statement
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. http://creativecommons.org/licenses/by-nc-nd/3.0/
Abstract
We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | physiology, biochemistry, systems biology, skeletal muscle |
| Research Division: | Biological Sciences |
| Research Group: | Zoology |
| Research Field: | Zoology not elsewhere classified |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the health sciences |
| UTAS Author: | Edwards, LM (Dr Lindsay Edwards) |
| UTAS Author: | Dwyer, RM (Dr Renee Ross) |
| UTAS Author: | Walls, JT (Professor Justin Walls) |
| UTAS Author: | Fuller, HJ (Dr Huddy Fuller) |
| ID Code: | 83179 |
| Year Published: | 2013 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Medicine |
| Deposited On: | 2013-03-05 |
| Last Modified: | 2017-11-07 |
| Downloads: | 340 View Download Statistics |
Repository Staff Only: item control page