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Beta-catenin expression is prognostic of improved non-small cell lung cancer survival


Chiu, CG and Chan, SK and Fang, ZA and Masoudi, H and Wood-Baker, R and Jones, SJM and Gilks, B and Laskin, J and Wiseman, SM, Beta-catenin expression is prognostic of improved non-small cell lung cancer survival, American Journal of Surgery, 203, (5) pp. 654-659. ISSN 0002-9610 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Elsevier Inc.

DOI: doi:10.1016/j.amjsurg.2012.01.002


INTRODUCTION: The objectives of this study were to determine the frequency and prognostic significance of beta-catenin expression in a cohort of non-small cell lung cancer (NSCLC) patients. METHODS: Tissue microarrays were constructed using clinically annotated formalin-fixed paraffin-embedded tumor samples from individuals diagnosed with NSCLC who underwent surgical resection with curative intent and had beta-catenin expression status determined by immunohistochemistry. RESULTS: Negative beta-catenin expression was seen in 28% (103/370) of NSCLC cases and was prognostic of a reduced overall patient survival (P = .008) and also was significantly correlated with the presence of lymphatic invasion (P = .015). In multivariate analysis, the loss of beta-catenin expression retained independent prognostic significance and showed an adjusted hazard ratio of 3.18 (confidence interval, 1.46-6.91, P = .004) for reduced patient survival when adjusting for the presence of lymphatic invasion, tumor grade, nodal status, and tumor stage. CONCLUSIONS: Beta-catenin represents an important prognostic marker in individuals diagnosed with surgically resectable NSCLC. © 2012 Elsevier Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer cell biology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wood-Baker, R (Professor Richard Wood-Baker)
ID Code:83059
Year Published:2012
Web of Science® Times Cited:17
Deposited By:Medicine
Deposited On:2013-02-28
Last Modified:2017-11-06

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