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Beta-catenin expression is prognostic of improved non-small cell lung cancer survival

journal contribution
posted on 2023-05-17, 16:18 authored by Chiu, CG, Chan, SK, Fang, ZA, Masoudi, H, Wood-Baker, R, Jones, SJM, Gilks, B, Laskin, J, Wiseman, SM
INTRODUCTION: The objectives of this study were to determine the frequency and prognostic significance of beta-catenin expression in a cohort of non-small cell lung cancer (NSCLC) patients. METHODS: Tissue microarrays were constructed using clinically annotated formalin-fixed paraffin-embedded tumor samples from individuals diagnosed with NSCLC who underwent surgical resection with curative intent and had beta-catenin expression status determined by immunohistochemistry. RESULTS: Negative beta-catenin expression was seen in 28% (103/370) of NSCLC cases and was prognostic of a reduced overall patient survival (P = .008) and also was significantly correlated with the presence of lymphatic invasion (P = .015). In multivariate analysis, the loss of beta-catenin expression retained independent prognostic significance and showed an adjusted hazard ratio of 3.18 (confidence interval, 1.46-6.91, P = .004) for reduced patient survival when adjusting for the presence of lymphatic invasion, tumor grade, nodal status, and tumor stage. CONCLUSIONS: Beta-catenin represents an important prognostic marker in individuals diagnosed with surgically resectable NSCLC. © 2012 Elsevier Inc.

History

Publication title

American Journal of Surgery

Volume

203

Issue

5

Pagination

654-659

ISSN

0002-9610

Department/School

Tasmanian School of Medicine

Publisher

Elsevier Inc.

Place of publication

1600 John F Kennedy Blvd, Philadelphia, USA

Rights statement

Copyright 2012 Elsevier Inc.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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