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Variable open-end wave reflection in the pulmonary arteries of anesthetized sheep
journal contribution
posted on 2023-05-17, 16:17 authored by Nathan DwyerNathan Dwyer, Yong, AC, David KilpatrickDavid KilpatrickThe aim of this study was to re-evaluate wave reflection in the healthy pulmonary arteries of sheep utilizing the time-domain-based method of wave intensity analysis. A thorough understanding of patterns of wave reflection during health and disease may provide future sensitive markers of early pulmonary vascular disease. Wave intensity was calculated from the simultaneous acquisition of proximal pulmonary arterial pressure and velocity in 12 anesthetized open-chest sheep. Normal pulmonary arterial wave speed was 2.1 ± 0.3 m s -1. The incident forward compression wave generated by right ventricular systole was reflected in an open-end manner as a backward expansion wave from a site 3 cm downstream, corresponding to the main pulmonary bifurcation, and in a closed-end manner as a backward compression wave from a site 21 cm downstream, corresponding to the pulmonary microcirculation. The proximal open-end reflection site was not present throughout the entire cardiac cycle. Wave reflection was minimal with only 1% of the incident forward compression wave energy reflected as a backward expansion wave and 2% as a backward compression wave. The normal pulmonary artery in open-chest sheep is characterized by variable proximal open-end reflection from the main pulmonary bifurcation and fixed closed-end reflection from the microcirculation, generating backwardtravelling waves of minimal intensity. © 2011 The Physiological Society of Japan and Springer.
History
Publication title
Journal of Physiological SciencesVolume
62Pagination
21-28ISSN
1880-6546Department/School
Tasmanian School of MedicinePublisher
Springer Japan KKPlace of publication
1-11-11 Kudan-kita, Tokyo, 102-0073 JapanRights statement
Copyright 2011 Physiological Society of Japan and Springer.Repository Status
- Restricted