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Variable open-end wave reflection in the pulmonary arteries of anesthetized sheep

Citation

Dwyer, N and Yong, AC and Kilpatrick, D, Variable open-end wave reflection in the pulmonary arteries of anesthetized sheep, Journal of Physiological Sciences, 62, (1) pp. 21-28. ISSN 1880-6546 (2012) [Refereed Article]

Copyright Statement

Copyright 2011 Physiological Society of Japan and Springer.

DOI: doi:10.1007/s12576-011-0182-7

Abstract

The aim of this study was to re-evaluate wave reflection in the healthy pulmonary arteries of sheep utilizing the time-domain-based method of wave intensity analysis. A thorough understanding of patterns of wave reflection during health and disease may provide future sensitive markers of early pulmonary vascular disease. Wave intensity was calculated from the simultaneous acquisition of proximal pulmonary arterial pressure and velocity in 12 anesthetized open-chest sheep. Normal pulmonary arterial wave speed was 2.1 ± 0.3 m s -1. The incident forward compression wave generated by right ventricular systole was reflected in an open-end manner as a backward expansion wave from a site 3 cm downstream, corresponding to the main pulmonary bifurcation, and in a closed-end manner as a backward compression wave from a site 21 cm downstream, corresponding to the pulmonary microcirculation. The proximal open-end reflection site was not present throughout the entire cardiac cycle. Wave reflection was minimal with only 1% of the incident forward compression wave energy reflected as a backward expansion wave and 2% as a backward compression wave. The normal pulmonary artery in open-chest sheep is characterized by variable proximal open-end reflection from the main pulmonary bifurcation and fixed closed-end reflection from the microcirculation, generating backwardtravelling waves of minimal intensity. © 2011 The Physiological Society of Japan and Springer.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Dwyer, N (Dr Nathan Dwyer)
Author:Yong, AC (Dr Ah Chot Yong)
Author:Kilpatrick, D (Professor David Kilpatrick)
ID Code:83037
Year Published:2012
Web of Science® Times Cited:10
Deposited By:Medicine (Discipline)
Deposited On:2013-02-27
Last Modified:2013-05-09
Downloads:0

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