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Acid-induced transient isotachophoretic stacking of basic drugs in co-electroosmotic flow capillary zone electrophoresis

Citation

Quirino, JP and Breadmore, MC, Acid-induced transient isotachophoretic stacking of basic drugs in co-electroosmotic flow capillary zone electrophoresis, Journal of Separation Science, 35, (1) pp. 60-65. ISSN 1615-9306 (2012) [Refereed Article]

Copyright Statement

Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

DOI: doi:10.1002/jssc.201100788

Abstract

Online sample concentration or stacking of basic drugs by transient isotachophoresis with the injection of an acid in co-electroosmotic flow capillary zone electrophoresis was studied experimentally and with computer simulation. The acid stacking strategy afforded an order of magnitude improvement in concentration sensitivity for model tricyclic antidepressant and β blocker drugs.

Item Details

Item Type:Refereed Article
Keywords:basic drugs, capillary zone electrophoresis, stacking
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Quirino, JP (Associate Professor Lito Quirino)
Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:83001
Year Published:2012
Web of Science® Times Cited:16
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2013-02-27
Last Modified:2013-04-23
Downloads:0

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