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Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2.6 years

Citation

Antony, B and Jones, G and Stannus, OP and Blizzard, L and Ding, C, Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2.6 years, Clinical Endocrinology, 79, (5) pp. 652-660. ISSN 1365-2265 (2013) [Refereed Article]

Copyright Statement

Copyright 2012 Blackwell Publishing Ltd

DOI: doi:10.1111/cen.12101

Abstract

Objective: Obesity is characterised by hyperinsulinemia, which is associated with diabetes, hypertension and coronary heart disease. The aim of this study was to determine if body fat and muscle measures predict the natural increase in leptin over 2.6 years in older adults.

Methods: 190 subjects (50% females) aged between 50 to 79 years were selected to perform the serum measurements for leptin. Height and weight were measured and body mass index (BMI) was calculated. Fat and lean mass of the whole body and the trunk were acquired through dual energy X-ray absorptiometry (DXA). Leg muscle strength and handgrip strength were measured using dynamometry.

Results: In multivariable analyses, leg muscle strength was negatively associated with both baseline leptin (β: -0.05 μg/l per Kg, 95% CI: -0.08, -0.02) and follow-up leptin (β: -0.04 μg/l per Kg, 95% CI: -0.07, -0.01). BMI, and percentage total fat and trunk fat and their respective change per annum (cpa) were significantly and positively associated with leptin. Lean mass was negatively associated with baseline leptin. Gender specific analyses produced similar associations between leg muscle strength, fat measures and follow-up leptin in males and females.

Conclusion: Besides positive associations between body fat, trunk fat and leptin, we found that leg muscle strength was negatively associated with leptin after 2.6 years in a sample of older population. This suggests interventions to maintain or increase muscle strength may have a protective effect on hyperleptinemia.

Item Details

Item Type:Refereed Article
Keywords:leptin, muscle strength, BMI, fat mass
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Antony, B (Mr Benny Eathakkattu Antony)
Author:Jones, G (Professor Graeme Jones)
Author:Stannus, OP (Mr Oliver Stannus)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:82712
Year Published:2013 (online first 2012)
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-02-14
Last Modified:2015-08-10
Downloads:0

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