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Ultraviolet radiation effects on the proteome of skin cells

Citation

Muller, HK and Woods, GM, Ultraviolet radiation effects on the proteome of skin cells, Advances in Experimental Medicine and Biology: Radiation Proteomics, Springer, D Leszczynski (ed), Dordrecht, Netherlands, pp. 111-119. ISBN 978-940075895-7 (2013) [Research Book Chapter]

Copyright Statement

Copyright 2013 Springer Science+Business Media Dordrecht

DOI: doi:10.1007/978-94-007-5896-4_8

Abstract

Proteomic studies to date have had limited use as an investigative tool in the skinís response to UV radiation. These studies used cell lines and reconstructed skin and have shown evidence of cell injury with oxidative damage and stress induced heat shock proteins. Others changes included altered cytokeratin and cytoskeletal proteins with enhanced expression of TRIM29 as the keratinocytes regenerate. The associated DNA repair requires polė, Rad18/Rad16 and Rev1. In the whole animal these events would be associated with inflammation, remodelling of the epidermis and modulation of the immune response. Longer term changes include ageing and skin cancers such as melanoma, squamous cell carcinoma and basal cell carcinoma. In the future proteomics will be used to explore these important aspects of photobiology. Better characterisation of the proteins involved should lead to a greater understanding of the skinís response to UV radiation.

Item Details

Item Type:Research Book Chapter
Keywords:proteome, skin, non-ionizing radiation, ultraviolet radiation, UV, UVA, UVB, UVC, acute effects, sunburn cells, keratinocyte, apoptosis, delayed effects, tanning, skin cancer, melanoma, immune system, Langerhans cells, immune suppression
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Muller, HK (Professor Konrad Muller)
Author:Woods, GM (Professor Gregory Woods)
ID Code:82616
Year Published:2013
Web of Science® Times Cited:12
Deposited By:Medicine (Discipline)
Deposited On:2013-02-07
Last Modified:2014-07-22
Downloads:5 View Download Statistics

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