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Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis

Citation

Yan, J and Liu, J and Lin, CY and Scott, RJ and Lechner-Scott, J and Brown, MA and Booth, DR and Stewart, GJ and Broadley, S and Mason, D and Griffiths, L and Moscato, P and Slee, M and Taylor, B and Wiley, J and Field, J and Butzkueven, H and Kilpatrick, TJ and Csurhes, PA and Pender, MP and McCombe, PA and Greer, JM, Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis, International Journal of Molecular Sciences, 13, (10) pp. 13667-13679. ISSN 1422-0067 (2012) [Refereed Article]


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Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0 http://creativecommons.org/licenses/by/3.0/

DOI: doi:10.3390/ijms131013667

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system. Although the exact pathogenesis of MS is unknown, it is generally considered to be an autoimmune disease, with numerous genetic and environmental factors determining disease susceptibility and severity. One important mediator of immune responses and inflammation is interleukin-6 (IL-6). Previously, elevated levels of IL-6 in mononuclear cells in blood and in brain tissue from MS patients have been reported. Various polymorphisms in the promoter region of the IL6 gene have also been linked with IL-6 protein levels. In MS, several small studies have investigated whether two IL6 promoter polymorphisms (-597 G>A and -174 G>C) correlate with MS susceptibility, but with varying results. In the present study, we analyzed these polymorphisms, together with an additional polymorphism (-572 G>C) in 279 healthy controls and 509 patients with MS. We found no significant differences between MS patients and healthy controls for the different -597 or -174 IL6 promoter alleles or genotypes. There was a slight reduction in the percentage of individuals with MS who carried a C allele at position -572, although this was not significant after correction for multiple comparisons. Interestingly, however, the -572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression.

Item Details

Item Type:Refereed Article
Keywords:multiple sclerosis, Interleukin-6, polymorphism, allele, genotype, disease progression
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Taylor, B (Professor Bruce Taylor)
ID Code:82586
Year Published:2012
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-02-07
Last Modified:2017-11-07
Downloads:293 View Download Statistics

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