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The influence of cytokines on wakefulness regulation: Clinical relevance, mechanisms and methodological problems


Weschenfelder, J and Sander, C and Kluge, M and Kirkby, KC and Himmerich, H, The influence of cytokines on wakefulness regulation: Clinical relevance, mechanisms and methodological problems, Psychiatria Danubina, 24, (2) pp. 112-126. ISSN 0353-5053 (2012) [Refereed Article]

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Copyright 2012 Medicinska naklada

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Sleep-wake-regulation has been shown to be substantially influenced by cytokines. The clinical relevance of this issue arises from (1) the frequency of accidents, injuries and impairment in social functioning due to sleepiness, (2) the occurrence of fatigue syndromes associated with inflammatory diseases, cancer or obesity, (3) the role of wakefulness regulation for the pathophysiology of affective and sleep disorders and (4) sedation as a side effect of psychopharmacological therapy. Experimental studies confirm the somnogenic influence of pro-inflammatory cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor- (TNF-). These cytokines modulate centers of wakefulness regulation located in the hypothalamus, the basal forebrain and the brain stem by influencing substances involved in sleep-wake-behavior such as adenosine, nitric oxide (NO), nuclear factor-B (NF-B), prostaglandin D2 (PGD2), the neurotransmitters -aminobutyric acid (GABA), glutamate and norepinephrine, as well as hormones such as growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH). Clinical studies of the influence of cytokines on wakefulness regulation are underrepresented in the research literature and objective measures of wakefulness such as the Multiple Sleep Latency Test (MSLT) are seldom reported.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Kirkby, KC (Professor Kenneth Kirkby)
ID Code:82537
Year Published:2012
Web of Science® Times Cited:24
Deposited By:Medicine
Deposited On:2013-02-06
Last Modified:2013-08-26

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