eCite Digital Repository
Persistent elevation of central pulse pressure during postural stress in patients with type 2 diabetes mellitus
Citation
Schultz, MG and Climie, RED and Nikolic, SB and Ahuja, KD and Sharman, JE, Persistent elevation of central pulse pressure during postural stress in patients with type 2 diabetes mellitus, Journal of Human Hypertension, 27, (7) pp. 437-444. ISSN 0950-9240 (2013) [Refereed Article]
Copyright Statement
Copyright 2012 Macmillan Publishers Limited
Abstract
An abnormal increase or decrease in blood pressure (BP) in response to postural stress is associated with increased risk of developing hypertension and stroke. However, the haemodynamic responses contributing to changes in central BP with postural stress are not well characterised. We aimed to determine this in controls compared to patients with type 2 diabetes mellitus (T2DM), whom we hypothesised would have an abnormal postural response. 41 participants (20 control, 21 T2DM) underwent measurement of brachial and central BP (by radial tonometry), with simultaneous bioimpedance cardiography (to determine stroke volume (SV) and cardiac output (CO)) and heart rate variability in seated and standing postures. Systemic vascular resistance (SVR; mean arterial pressure/CO), and arterial elastance (E(A); end systolic pressure/SV) were calculated. Postural changes were defined as seated minus standing values. Central pulse pressure (PP) was higher in patients with T2DM and did not change from seated-to-standing positions, whereas there was a significant decrease upon standing in controls (P < 0.05). The change in central systolic BP (SBP) correlated with change in SVR and EA in controls (r = 0.67 and 0.68, P < 0.05, respectively), but not in patients with T2DM (r = -0.05 and r = 0.03, P > 0.05, respectively). SV was the only significant correlate of change in central SBP in T2DM patients (r = 0.62, P < 0.05) and this was not observed in controls (r = -0.08 P > 0.05). We conclude that central haemodynamic responses to postural stress are altered in patients with T2DM and result in persistent elevation of central PP while standing. This may contribute to increased cardiovascular risk associated with T2DM.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | haemodynamics, type 2 diabetes, pulse wave analysis, posture |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Schultz, MG (Dr Martin Schultz) |
UTAS Author: | Climie, RED (Dr Rachel Climie) |
UTAS Author: | Nikolic, SB (Mrs Sonja Nikolic) |
UTAS Author: | Ahuja, KD (Dr Kiran Ahuja) |
UTAS Author: | Sharman, JE (Professor James Sharman) |
ID Code: | 82483 |
Year Published: | 2013 (online first 2012) |
Web of Science® Times Cited: | 8 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2013-02-05 |
Last Modified: | 2017-11-02 |
Downloads: | 0 |
Repository Staff Only: item control page