Juonala, M and Jaaskelainen, P and Sabin, MA and Viikari, JSA and Kahonen, M and Lehtimaki, T and Seppala, I and Hutri-Kahonen, N and Taittonen, L and Jokinen, E and Laitinen, T and Magnussen, CG and Raitakari, OT, Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring, Journal of Pediatrics, 162, (5) pp. 918-923. ISSN 0022-3476 (2013) [Refereed Article]
Copyright 2013 Mosby.
Objectives: To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors.
Study design: The analyses were based on the Cardiovascular Risk in Young Finns Study including 1835 individuals aged 3-18 years at baseline with data on maternal BMI, childhood metabolic factors, as well as 34 newly identified type 2 diabetes susceptibility alleles. These subjects were then followed-up over 21-27 years.
Results: Maternal BMI (OR for 1-SD increase 1.54 [95% CI 1.12-2.11], P = .008) and child's systolic blood pressure (1.54 [1.01-2.35], P = .04) were significantly associated with increased odds for later type 2 diabetes, in a multivariable analysis adjusted for age, sex, type 2 diabetes genetic risk score, childhood BMI, insulin, lipids, dietary factors, socioeconomic status, and mother's age, and history of type 2 diabetes. A risk prediction model, which included maternal BMI status outperformed one which utilized only child's BMI data (area under the receiver operating characteristic curve 0.720 vs 0.623, P = .02). The inclusion of genetic risk score and other baseline risk variables did not additionally improve prediction (area under the receiver operating characteristic curve 0.720 vs 0.745, P = .40).
Conclusions: Maternal BMI is a useful variable in determining offspring risk of developing type 2 diabetes.
|Item Type:||Refereed Article|
|Keywords:||body mass index, risk factors, obesity, type 2 diabetes, maternal|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|Web of Science® Times Cited:||12|
|Deposited By:||Menzies Institute for Medical Research|
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