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Body fat is associated with increased and lean mass with decreased knee cartilage loss in older adults: a prospective cohort study

Citation

Ding, C and Stannus, OP and Cicuttini, F and Antony, B and Jones, G, Body fat is associated with increased and lean mass with decreased knee cartilage loss in older adults: a prospective cohort study, International Journal of Obesity, 32 pp. 822-827. ISSN 0307-0565 (2012) [Refereed Article]

Copyright Statement

Copyright 2013 Nature Publishing Group

DOI: doi:10.1038/ijo.2012.136

Abstract

Objective: To determine the associations between body composition at baseline and knee cartilage loss over 2.9 years in older adults.

Methods: A total of 395 randomly selected subjects (mean 62 years, range 51-81, 50% female) were studied at baseline and 2.9 years later. T1-weighted fat-suppressed magnetic resonance imaging of the right knee was performed to determine knee cartilage volume and tibial bone area at baseline and follow-up. Height, weight and radiographic osteoarthritis were measured by standard protocols at baseline. Fat mass and lean mass were measured by dual-energy X-ray absorptiometry at baseline.

Results: Tibial cartilage volume decreased by 2.02.7% per annum. In multivariable analysis, annual change in medial cartilage volume was negatively and significantly associated with body mass index (β: −0.14% per kg m−2, 95% confidence interval (CI): −0.25%, −0.02%), percentage total body fat (β: −0.19% per %, 95% CI: −0.30%, −0.07%) and percentage trunk fat (β: −0.10% per %, 95% CI: −0.19%, −0.02%), and positively associated with percentage lean mass (β: 0.20% per %, 95% CI: 0.08%, 0.32%). Change in lateral tibial cartilage volume was also significantly associated with percentage total body fat (β: −0.11% per %, 95% CI: −0.21%, −0.001%) and total lean mass (β: 0.13% per kg, 95% CI: 0.04%, 0.22%). These were independent of sex and age even though both were also significant predictors.

Conclusions: Body fat adversely affects tibial cartilage loss over time, whereas lean mass is protective. Strategies aimed at reducing body fat but increasing lean mass may reduce knee cartilage loss in older people.

Item Details

Item Type:Refereed Article
Keywords:cartilage volume, body fat, lean mass, osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Stannus, OP (Mr Oliver Stannus)
Author:Antony, B (Mr Benny Eathakkattu Antony)
Author:Jones, G (Professor Graeme Jones)
ID Code:82371
Year Published:2012
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-01-29
Last Modified:2017-11-02
Downloads:0

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