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Use of suppressors for signal enhancement of weakly-acidic analytes in ion chromatography with universal detection methods
Suppression has enabled ion chromatography (IC) to be established as the leading technique for analysis of strong acids and bases. However, the determination of weakly-ionized species (e.g., weak organic acids) by IC is challenging due to the low conductance of the analytes after ion suppression. Moreover, when weak acids or bases have low absorbance, other universal detection methods are required for successful analysis, but the use of non-volatile ionic eluents in IC frequently prevents this option being used.
We review different approaches to the conductivity detection of weakly-ionized analytes, with emphasis on the role of suppressors for conductivity-signal enhancement through the use of post-column ion-exchange reactions. We provide typical signal-enhancement factors for each method.
This review also focuses on the use of suppressors as eluent de-salting devices to enable coupling of IC to universal detectors (e.g., mass spectrometry), evaporative light-scattering detectors and charged-aerosol detectors.History
Publication title
TrAC Trends in Analytical ChemistryVolume
40Pagination
119-132ISSN
0165-9936Department/School
School of Natural SciencesPublisher
Elsevier Science LondonPlace of publication
84 Theobalds Rd, London, England, Wc1X 8RrRights statement
Crown Copyright 2012Repository Status
- Restricted