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Determination of pharmaceutically related compounds by suppressed ion chromatography: III. Role of electrolytic suppressor design

Citation

Karu, N and Dicinoski, GW and Hanna-Brown, M and Srinivasan, K and Pohl, CA and Haddad, PR, Determination of pharmaceutically related compounds by suppressed ion chromatography: III. Role of electrolytic suppressor design, Journal of Chromatography A, 1233 pp. 71-77. ISSN 0021-9673 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Elsevier B.V.

DOI: doi:10.1016/j.chroma.2012.02.008

Abstract

For the hyphenation of ion chromatography to nebulising detectors or mass spectrometry, suppression of the non-volatile ionic eluent to water is a required step to avoid elevated detector baselines. Presented here is a study of three new designs of electrolytic suppressors, incorporating high ion-exchange capacity screens and high ion-exchange capacity membranes in different thickness and compositions. These designs aim to minimise hydrophobic interactions of the suppressor with organic analytes and to provide higher compatibility with eluents containing acetonitrile. In comparison with a commercially available electrolytic suppressor and also a commercially available chemical suppressor, the new highcapacity suppressor showed superior performance, exhibiting minimal interactions with a test set of analytes under the examined conditions. This led to the attainment of high recoveries of the analytes after suppression (9399% recovery) and significantly reduced band broadening during suppression. The new suppressor has been shown to perform well under both isocratic and gradient elution conditions.

Item Details

Item Type:Refereed Article
Keywords:ion chromatography, suppressor designs, pharmaceuticals
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Karu, N (Dr Naama Karu)
Author:Dicinoski, GW (Associate Professor Gregory Dicinoski)
Author:Haddad, PR (Professor Paul Haddad)
ID Code:82362
Year Published:2012
Web of Science® Times Cited:5
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2013-01-29
Last Modified:2013-04-22
Downloads:0

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