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Determination of pharmaceutically related compounds by suppressed ion chromatography: III. Role of electrolytic suppressor design
journal contribution
posted on 2023-05-17, 15:38 authored by Karu, N, Gregory Dicinoski, Hanna-Brown, M, Srinivasan, K, Pohl, CA, Paul HaddadPaul HaddadFor the hyphenation of ion chromatography to nebulising detectors or mass spectrometry, suppression of the non-volatile ionic eluent to water is a required step to avoid elevated detector baselines. Presented here is a study of three new designs of electrolytic suppressors, incorporating high ion-exchange capacity screens and high ion-exchange capacity membranes in different thickness and compositions. These designs aim to minimise hydrophobic interactions of the suppressor with organic analytes and to provide higher compatibility with eluents containing acetonitrile. In comparison with a commercially available electrolytic suppressor and also a commercially available chemical suppressor, the new highcapacity suppressor showed superior performance, exhibiting minimal interactions with a test set of analytes under the examined conditions. This led to the attainment of high recoveries of the analytes after suppression (93–99% recovery) and significantly reduced band broadening during suppression. The new suppressor has been shown to perform well under both isocratic and gradient elution conditions.
History
Publication title
Journal of Chromatography AVolume
1233Pagination
71-77ISSN
0021-9673Department/School
School of Natural SciencesPublisher
Elsevier Science BvPlace of publication
Po Box 211, Amsterdam, Netherlands, 1000 AeRights statement
Copyright 2012 Elsevier B.V.Repository Status
- Restricted