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Mechanisms of Transthyretin Aggregation and Toxicity
chapter
posted on 2023-05-22, 13:55 authored by Robert GasperiniRobert Gasperini, Klaver, DW, Hou, X, Aguilar, MI, David SmallDavid SmallAmyloidoses are characterised by the deposition of insoluble protein that occurs in the extracellular compartment of various tissues. One form of amyloidosis is caused by transthyretin (TTR) misfolding and deposition in target tissues. It is clear that many amyloidoses share common features of fibrillogenesis and toxicity. This chapter examines the mechanisms of TTR aggregation with a view to understanding the possible therapeutic interventions in amyloid disease.
History
Publication title
Protein Aggregation and Fibrillogenesis in Cerebral and Systematic Amyloid Disease, Subcellular Biochemistry 65Volume
65Editors
JR HarrisPagination
211-224ISBN
978-94-007-5415-7Department/School
Menzies Institute for Medical ResearchPublisher
SpringerPlace of publication
DordrechtExtent
22Rights statement
Copyright 2012 Springer Science+Business Media DordrechtRepository Status
- Restricted