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Mechanisms of Transthyretin Aggregation and Toxicity

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posted on 2023-05-22, 13:55 authored by Robert GasperiniRobert Gasperini, Klaver, DW, Hou, X, Aguilar, MI, David SmallDavid Small
Amyloidoses are characterised by the deposition of insoluble protein that occurs in the extracellular compartment of various tissues. One form of amyloidosis is caused by transthyretin (TTR) misfolding and deposition in target tissues. It is clear that many amyloidoses share common features of fibrillogenesis and toxicity. This chapter examines the mechanisms of TTR aggregation with a view to understanding the possible therapeutic interventions in amyloid disease.

History

Publication title

Protein Aggregation and Fibrillogenesis in Cerebral and Systematic Amyloid Disease, Subcellular Biochemistry 65

Volume

65

Editors

JR Harris

Pagination

211-224

ISBN

978-94-007-5415-7

Department/School

Menzies Institute for Medical Research

Publisher

Springer

Place of publication

Dordrecht

Extent

22

Rights statement

Copyright 2012 Springer Science+Business Media Dordrecht

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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