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Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum

Citation

McMorran, BJ and Wieczorski, L and Drysdale, KE and Chan, J-A and Huang, HM and Smith, C and Mitiku, C and Beeson, JG and Burgio, G and Foote, SJ, Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum, Science, 338, (6112) pp. 1348-1351. ISSN 0036-8075 (2012) [Refereed Article]


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DOI: doi:10.1126/science.1228892

Abstract

Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically dependent on Fy, which binds PF4. Genetic disruption of Fy expression inhibits binding of PF4 to parasitized cells and concomitantly prevents parasite killing by both human platelets and recombinant human PF4. The protective function afforded by platelets during a malarial infection may therefore be compromised in Duffy-negative individuals, who do not express Fy.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Parasitology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:McMorran, BJ (Dr Brendan McMorran)
Author:Wieczorski, L (Ms Laura Wieczorski)
Author:Drysdale, KE (Ms Karen Drysdale)
Author:Smith, C (Dr Clare Smith)
Author:Mitiku, C (Mr Chalachew Mitiku)
Author:Burgio, G (Dr Gaetan Burgio)
Author:Foote, SJ (Professor Simon Foote)
ID Code:82091
Year Published:2012
Funding Support:National Health and Medical Research Council (605524)
Web of Science® Times Cited:62
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-01-16
Last Modified:2017-11-06
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