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Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement
Schoels, MM and van der Heijde, D and Breedveld, FC and Burmester, GR and Dougados, M and Emery, P and Ferraccioli, G and Gabay, C and Gibofsky, A and Gomez-Reino, JJ and Jones, G and Kvien, TK and Murikama, MM and Nishimoto, N and Smolen, JS, Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement, Annals of the Rheumatic Diseases, 72 pp. 583-589. ISSN 0003-4967 (2013) [Refereed Article]
Copyright 2013 BMJ
Background: Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects constitutes a therapeutic option for chronic inflammatory diseases. Tocilizumab is the only IL-6 inhibitor (IL-6i) licensed for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), but also other agents targeting either IL-6 or its receptor are investigated in various indications.
Objective: To review published evidence on safety and efficacy of IL-6i in inflammatory diseases.
Methods: We performed systematic literature searches in Medline and Cochrane, screened EULAR and American College of Rheumatology meeting-abstracts, and accessed http://www.clinicaltrials.gov.
Results: Comprehensive evidence supports the efficacy of tocilizumab in RA in DMARD-na´ve patients, and after DMARD- and TNFi-failure. Randomised comparisons demonstrate superiority of tocilizumab in JIA, but not ankylosing spondylitis (AS). Other indications are currently investigated. Additional IL-6i show similar efficacy; safety generally appears acceptable.
Conclusions: IL-6i is effective and safe in RA and JIA, but not in AS. Preliminary results in other indications need substantiation.
|Item Type:||Refereed Article|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|Year Published:||2013 (online first 2012)|
|Web of Science® Times Cited:||67|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||394 View Download Statistics|
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