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Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement

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Schoels, MM and van der Heijde, D and Breedveld, FC and Burmester, GR and Dougados, M and Emery, P and Ferraccioli, G and Gabay, C and Gibofsky, A and Gomez-Reino, JJ and Jones, G and Kvien, TK and Murikama, MM and Nishimoto, N and Smolen, JS, Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement, Annals of the Rheumatic Diseases, 72 pp. 583-589. ISSN 0003-4967 (2013) [Refereed Article]


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Copyright Statement

Copyright 2013 BMJ

DOI: doi:10.1136/annrheumdis-2012-202470

Abstract

Background: Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects constitutes a therapeutic option for chronic inflammatory diseases. Tocilizumab is the only IL-6 inhibitor (IL-6i) licensed for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), but also other agents targeting either IL-6 or its receptor are investigated in various indications.

Objective: To review published evidence on safety and efficacy of IL-6i in inflammatory diseases.

Methods: We performed systematic literature searches in Medline and Cochrane, screened EULAR and American College of Rheumatology meeting-abstracts, and accessed http://www.clinicaltrials.gov.

Results: Comprehensive evidence supports the efficacy of tocilizumab in RA in DMARD-na´ve patients, and after DMARD- and TNFi-failure. Randomised comparisons demonstrate superiority of tocilizumab in JIA, but not ankylosing spondylitis (AS). Other indications are currently investigated. Additional IL-6i show similar efficacy; safety generally appears acceptable.

Conclusions: IL-6i is effective and safe in RA and JIA, but not in AS. Preliminary results in other indications need substantiation.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
ID Code:82084
Year Published:2013 (online first 2012)
Web of Science® Times Cited:45
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-01-16
Last Modified:2013-11-20
Downloads:248 View Download Statistics

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